Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives
Number of heterocyclic compounds has been exploited to develop pharmaceutically important molecules, out of which biheterocyclic coumarins are clinically used potential drug candidates showing oral hypoglycemic and antidiabetic activities. A new series of 3-[5'-methyl-2'-aryl-3'-(thia...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/258680 |
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| _version_ | 1832551113127100416 |
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| author | Deepthi Kini Manjunath Ghate |
| author_facet | Deepthi Kini Manjunath Ghate |
| author_sort | Deepthi Kini |
| collection | DOAJ |
| description | Number of heterocyclic compounds has been exploited to develop pharmaceutically important molecules, out of which biheterocyclic coumarins are clinically used potential drug candidates showing oral hypoglycemic and antidiabetic activities. A new series of 3-[5'-methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino)thiazolidin-4'-one]coumarin derivatives were designed and synthesized. The title compounds were synthesized from starting material 3- acetyl coumarin. All the synthesized compounds were characterized and screened for hypoglycemic activity. Some of the compounds exhibited promising activity. |
| format | Article |
| id | doaj-art-5beac5ec678e42a2b960eea735ff95f1 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-5beac5ec678e42a2b960eea735ff95f12025-02-03T06:04:57ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018138639010.1155/2011/258680Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin DerivativesDeepthi Kini0Manjunath Ghate1Department of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Bangalore, IndiaDepartment of Pharmaceutical Chemistry, Institute of Pharmacy Nirma University, Ahmedabad-382 481, IndiaNumber of heterocyclic compounds has been exploited to develop pharmaceutically important molecules, out of which biheterocyclic coumarins are clinically used potential drug candidates showing oral hypoglycemic and antidiabetic activities. A new series of 3-[5'-methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino)thiazolidin-4'-one]coumarin derivatives were designed and synthesized. The title compounds were synthesized from starting material 3- acetyl coumarin. All the synthesized compounds were characterized and screened for hypoglycemic activity. Some of the compounds exhibited promising activity.http://dx.doi.org/10.1155/2011/258680 |
| spellingShingle | Deepthi Kini Manjunath Ghate Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives E-Journal of Chemistry |
| title | Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives |
| title_full | Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives |
| title_fullStr | Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives |
| title_full_unstemmed | Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives |
| title_short | Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives |
| title_sort | synthesis and oral hypoglycemic activity of 3 5 methyl 2 aryl 3 thiazol 2 yl amino thiazolidin 4 one coumarin derivatives |
| url | http://dx.doi.org/10.1155/2011/258680 |
| work_keys_str_mv | AT deepthikini synthesisandoralhypoglycemicactivityof35methyl2aryl3thiazol2ʺylaminothiazolidin4onecoumarinderivatives AT manjunathghate synthesisandoralhypoglycemicactivityof35methyl2aryl3thiazol2ʺylaminothiazolidin4onecoumarinderivatives |