Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ disease
It has been reported that Graves’ disease (GD) sometimes improves spontaneously during pregnancy, although exacerbation of GD during postpartum period or relapse of hyperthyroidism caused by GD might occur. This study aimed to investigate the incidence of postpartum diagnosis of thyroid eye disease...
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| Language: | English |
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The Japan Endocrine Society
2025-01-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/72/1/72_EJ24-0401/_html/-char/en |
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| author | Nami Suzuki Jaeduk Yoshimura Noh Ai Kozaki Natsuko Watanabe Ai Yoshihara Miho Fukushita Masako Matsumoto Hideyuki Imai Shigenori Hiruma Masahiro Ichikawa Masakazu Koshibu Akiko Sankoda Rei Hirose Toshu Inoue Kiminori Sugino Koichi Ito |
| author_facet | Nami Suzuki Jaeduk Yoshimura Noh Ai Kozaki Natsuko Watanabe Ai Yoshihara Miho Fukushita Masako Matsumoto Hideyuki Imai Shigenori Hiruma Masahiro Ichikawa Masakazu Koshibu Akiko Sankoda Rei Hirose Toshu Inoue Kiminori Sugino Koichi Ito |
| author_sort | Nami Suzuki |
| collection | DOAJ |
| description | It has been reported that Graves’ disease (GD) sometimes improves spontaneously during pregnancy, although exacerbation of GD during postpartum period or relapse of hyperthyroidism caused by GD might occur. This study aimed to investigate the incidence of postpartum diagnosis of thyroid eye disease (TED) in relation to thyroid dysfunction. This retrospective cross-sectional study enrolled 11,104 deliveries from the patients with GD between January 2004 and August 2022. Within the 12-month postpartum period, 72 patients (0.65%) were diagnosed with TED. The thyroid function of the 72 patients comprised 9 remission, 13 continued antithyroid medicine, and 50 thyroid dysfunction; 30 newly diagnosed GD, 1 hypothyroidism, and 19 relapse/recurrence of GD. In the 49 patients with thyroid dysfunction, no difference was observed in the median values of thyroid-stimulating hormone (TSH) receptor antibody (TRAb) and TSH receptor stimulating antibody between the TED diagnosis and the development of hyperthyroidism. However, when the patients were classified into the newly developed GD and relapse/recurrence of GD groups, the difference became significant and the TRAb level was high in the newly developed GD (16.1 vs. 5.0 IU/L, p < 0.0001, and 15.0 vs. 6.0 IU/L, p = 0.0003). Thyroid dysfunction preceded TED diagnosis in more than half of the patients and the median time for each event was 6.5 vs. 8.1 months. The active phase TED was observed in 8 of the 72 patients. Of the 72 patients newly diagnosed with TED in postpartum, two-thirds were accompanied by thyroid dysfunction and 8 of them were in active phase. |
| format | Article |
| id | doaj-art-5bd2a5006d244794912475701e677f9c |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-5bd2a5006d244794912475701e677f9c2025-01-22T05:36:47ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402025-01-0172110311310.1507/endocrj.EJ24-0401endocrjIncidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ diseaseNami Suzuki0Jaeduk Yoshimura Noh1Ai Kozaki2Natsuko Watanabe3Ai Yoshihara4Miho Fukushita5Masako Matsumoto6Hideyuki Imai7Shigenori Hiruma8Masahiro Ichikawa9Masakazu Koshibu10Akiko Sankoda11Rei Hirose12Toshu Inoue13Kiminori Sugino14Koichi Ito15Department of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Ophthalmology, Olympia Eye Hospital, Tokyo 150-0001, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Ophthalmology, Olympia Eye Hospital, Tokyo 150-0001, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanIt has been reported that Graves’ disease (GD) sometimes improves spontaneously during pregnancy, although exacerbation of GD during postpartum period or relapse of hyperthyroidism caused by GD might occur. This study aimed to investigate the incidence of postpartum diagnosis of thyroid eye disease (TED) in relation to thyroid dysfunction. This retrospective cross-sectional study enrolled 11,104 deliveries from the patients with GD between January 2004 and August 2022. Within the 12-month postpartum period, 72 patients (0.65%) were diagnosed with TED. The thyroid function of the 72 patients comprised 9 remission, 13 continued antithyroid medicine, and 50 thyroid dysfunction; 30 newly diagnosed GD, 1 hypothyroidism, and 19 relapse/recurrence of GD. In the 49 patients with thyroid dysfunction, no difference was observed in the median values of thyroid-stimulating hormone (TSH) receptor antibody (TRAb) and TSH receptor stimulating antibody between the TED diagnosis and the development of hyperthyroidism. However, when the patients were classified into the newly developed GD and relapse/recurrence of GD groups, the difference became significant and the TRAb level was high in the newly developed GD (16.1 vs. 5.0 IU/L, p < 0.0001, and 15.0 vs. 6.0 IU/L, p = 0.0003). Thyroid dysfunction preceded TED diagnosis in more than half of the patients and the median time for each event was 6.5 vs. 8.1 months. The active phase TED was observed in 8 of the 72 patients. Of the 72 patients newly diagnosed with TED in postpartum, two-thirds were accompanied by thyroid dysfunction and 8 of them were in active phase.https://www.jstage.jst.go.jp/article/endocrj/72/1/72_EJ24-0401/_html/-char/enthyroid eye diseasethyroid orbitopathygraves’ diseasepostpartum |
| spellingShingle | Nami Suzuki Jaeduk Yoshimura Noh Ai Kozaki Natsuko Watanabe Ai Yoshihara Miho Fukushita Masako Matsumoto Hideyuki Imai Shigenori Hiruma Masahiro Ichikawa Masakazu Koshibu Akiko Sankoda Rei Hirose Toshu Inoue Kiminori Sugino Koichi Ito Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ disease Endocrine Journal thyroid eye disease thyroid orbitopathy graves’ disease postpartum |
| title | Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ disease |
| title_full | Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ disease |
| title_fullStr | Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ disease |
| title_full_unstemmed | Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ disease |
| title_short | Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves’ disease |
| title_sort | incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in graves disease |
| topic | thyroid eye disease thyroid orbitopathy graves’ disease postpartum |
| url | https://www.jstage.jst.go.jp/article/endocrj/72/1/72_EJ24-0401/_html/-char/en |
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