Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat
Sleep pattern disruption, specifically REM sleep behavior disorder (RBD), is a major nonmotor cause of disability in PD. Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments. 24-hour polysomnography (PSG), the gold standard for sleep studies,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2014/852965 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545435040874496 |
|---|---|
| author | Quynh Vo Timothy P. Gilmour Kala Venkiteswaran Jidong Fang Thyagarajan Subramanian |
| author_facet | Quynh Vo Timothy P. Gilmour Kala Venkiteswaran Jidong Fang Thyagarajan Subramanian |
| author_sort | Quynh Vo |
| collection | DOAJ |
| description | Sleep pattern disruption, specifically REM sleep behavior disorder (RBD), is a major nonmotor cause of disability in PD. Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments. 24-hour polysomnography (PSG), the gold standard for sleep studies, has never been used to test sleep dysfunction in the standard 6-OHDA lesioned hemiparkinsonian (HP) rat PD model. In this study, we recorded 24-hour PSG from normal and HP rats. Recordings were scored into wake, rapid eye movement (REM), and non-REM (NREM). We then examined EEG to identify REM periods and EMG to check muscle activity during REM. Normal rats showed higher wakefulness (70–80%) during the dark phase and lower wakefulness (20%) during the light phase. HP rats showed 30–50% sleep in both phases, less modulation and synchronization to the light schedule (P<0.0001), and more long run lengths of wakefulness (P<0.05). HP rats also had more REM epochs with muscle activity than control rats (P<0.05). Our findings that the sleep architecture in the HP rat resembles that of PD patients demonstrate the value of this model in studying the pathophysiological basis of PD sleep disturbances and preclinical therapeutics for PD related sleep disorders including RBD. |
| format | Article |
| id | doaj-art-5bd00839e44e46c9b708b6957f02432b |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-5bd00839e44e46c9b708b6957f02432b2025-02-03T07:25:42ZengWileyParkinson's Disease2090-80832042-00802014-01-01201410.1155/2014/852965852965Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian RatQuynh Vo0Timothy P. Gilmour1Kala Venkiteswaran2Jidong Fang3Thyagarajan Subramanian4Department of Neurology, Penn State College of Medicine, Hershey, PA 17033, USADivision of Engineering, John Brown University, Siloam Springs, AR 72761, USADepartment of Neurology, Penn State College of Medicine, Hershey, PA 17033, USADepartment of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USADepartment of Neurology, Penn State College of Medicine, Hershey, PA 17033, USASleep pattern disruption, specifically REM sleep behavior disorder (RBD), is a major nonmotor cause of disability in PD. Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments. 24-hour polysomnography (PSG), the gold standard for sleep studies, has never been used to test sleep dysfunction in the standard 6-OHDA lesioned hemiparkinsonian (HP) rat PD model. In this study, we recorded 24-hour PSG from normal and HP rats. Recordings were scored into wake, rapid eye movement (REM), and non-REM (NREM). We then examined EEG to identify REM periods and EMG to check muscle activity during REM. Normal rats showed higher wakefulness (70–80%) during the dark phase and lower wakefulness (20%) during the light phase. HP rats showed 30–50% sleep in both phases, less modulation and synchronization to the light schedule (P<0.0001), and more long run lengths of wakefulness (P<0.05). HP rats also had more REM epochs with muscle activity than control rats (P<0.05). Our findings that the sleep architecture in the HP rat resembles that of PD patients demonstrate the value of this model in studying the pathophysiological basis of PD sleep disturbances and preclinical therapeutics for PD related sleep disorders including RBD.http://dx.doi.org/10.1155/2014/852965 |
| spellingShingle | Quynh Vo Timothy P. Gilmour Kala Venkiteswaran Jidong Fang Thyagarajan Subramanian Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat Parkinson's Disease |
| title | Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat |
| title_full | Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat |
| title_fullStr | Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat |
| title_full_unstemmed | Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat |
| title_short | Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat |
| title_sort | polysomnographic features of sleep disturbances and rem sleep behavior disorder in the unilateral 6 ohda lesioned hemiparkinsonian rat |
| url | http://dx.doi.org/10.1155/2014/852965 |
| work_keys_str_mv | AT quynhvo polysomnographicfeaturesofsleepdisturbancesandremsleepbehaviordisorderintheunilateral6ohdalesionedhemiparkinsonianrat AT timothypgilmour polysomnographicfeaturesofsleepdisturbancesandremsleepbehaviordisorderintheunilateral6ohdalesionedhemiparkinsonianrat AT kalavenkiteswaran polysomnographicfeaturesofsleepdisturbancesandremsleepbehaviordisorderintheunilateral6ohdalesionedhemiparkinsonianrat AT jidongfang polysomnographicfeaturesofsleepdisturbancesandremsleepbehaviordisorderintheunilateral6ohdalesionedhemiparkinsonianrat AT thyagarajansubramanian polysomnographicfeaturesofsleepdisturbancesandremsleepbehaviordisorderintheunilateral6ohdalesionedhemiparkinsonianrat |