The Impact of Autophagy on Cell Death Modalities
Autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins, through a lysosome-dependent degradation pathway. During starvation, autophagy facilitates cell survival through the recycling of metabolic precursors. Additionally, autophagy can modulate other vital...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/502676 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566539000217600 |
|---|---|
| author | Stefan W. Ryter Kenji Mizumura Augustine M. K. Choi |
| author_facet | Stefan W. Ryter Kenji Mizumura Augustine M. K. Choi |
| author_sort | Stefan W. Ryter |
| collection | DOAJ |
| description | Autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins, through a lysosome-dependent degradation pathway. During starvation, autophagy facilitates cell survival through the recycling of metabolic precursors. Additionally, autophagy can modulate other vital processes such as programmed cell death (e.g., apoptosis), inflammation, and adaptive immune mechanisms and thereby influence disease pathogenesis. Selective pathways can target distinct cargoes (e.g., mitochondria and proteins) for autophagic degradation. At present, the causal relationship between autophagy and various forms of regulated or nonregulated cell death remains unclear. Autophagy can occur in association with necrosis-like cell death triggered by caspase inhibition. Autophagy and apoptosis have been shown to be coincident or antagonistic, depending on experimental context, and share cross-talk between signal transduction elements. Autophagy may modulate the outcome of other regulated forms of cell death such as necroptosis. Recent advances suggest that autophagy can dampen inflammatory responses, including inflammasome-dependent caspase-1 activation and maturation of proinflammatory cytokines. Autophagy may also act as regulator of caspase-1 dependent cell death (pyroptosis). Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases in which apoptosis or other forms of regulated cell death may play a cardinal role. |
| format | Article |
| id | doaj-art-5bca913972a744e29a65adc7571041e3 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-5bca913972a744e29a65adc7571041e32025-02-03T01:03:45ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/502676502676The Impact of Autophagy on Cell Death ModalitiesStefan W. Ryter0Kenji Mizumura1Augustine M. K. Choi2Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USAPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USAWeil Cornell Medical College, 525 East 68th Street, Room M-522, Box 130, New York, NY 10065, USAAutophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins, through a lysosome-dependent degradation pathway. During starvation, autophagy facilitates cell survival through the recycling of metabolic precursors. Additionally, autophagy can modulate other vital processes such as programmed cell death (e.g., apoptosis), inflammation, and adaptive immune mechanisms and thereby influence disease pathogenesis. Selective pathways can target distinct cargoes (e.g., mitochondria and proteins) for autophagic degradation. At present, the causal relationship between autophagy and various forms of regulated or nonregulated cell death remains unclear. Autophagy can occur in association with necrosis-like cell death triggered by caspase inhibition. Autophagy and apoptosis have been shown to be coincident or antagonistic, depending on experimental context, and share cross-talk between signal transduction elements. Autophagy may modulate the outcome of other regulated forms of cell death such as necroptosis. Recent advances suggest that autophagy can dampen inflammatory responses, including inflammasome-dependent caspase-1 activation and maturation of proinflammatory cytokines. Autophagy may also act as regulator of caspase-1 dependent cell death (pyroptosis). Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases in which apoptosis or other forms of regulated cell death may play a cardinal role.http://dx.doi.org/10.1155/2014/502676 |
| spellingShingle | Stefan W. Ryter Kenji Mizumura Augustine M. K. Choi The Impact of Autophagy on Cell Death Modalities International Journal of Cell Biology |
| title | The Impact of Autophagy on Cell Death Modalities |
| title_full | The Impact of Autophagy on Cell Death Modalities |
| title_fullStr | The Impact of Autophagy on Cell Death Modalities |
| title_full_unstemmed | The Impact of Autophagy on Cell Death Modalities |
| title_short | The Impact of Autophagy on Cell Death Modalities |
| title_sort | impact of autophagy on cell death modalities |
| url | http://dx.doi.org/10.1155/2014/502676 |
| work_keys_str_mv | AT stefanwryter theimpactofautophagyoncelldeathmodalities AT kenjimizumura theimpactofautophagyoncelldeathmodalities AT augustinemkchoi theimpactofautophagyoncelldeathmodalities AT stefanwryter impactofautophagyoncelldeathmodalities AT kenjimizumura impactofautophagyoncelldeathmodalities AT augustinemkchoi impactofautophagyoncelldeathmodalities |