New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer Activity
A new ligand (5-(2-benzamido-N-methylacetamido)-4-((3,4,5-trimethoxycyclohexa-1,3-dien-1-yl) methyl) pyrimidine-2-yl) amino)boric acid was synthesized by the reaction of trimethoprim amide derivative with boric acid, as well as its metal complexes with Co (II), Ni (II), and Pt (IV). Spectral method...
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University of Baghdad
2025-01-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
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| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3418 |
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| author | Alaa Abdullah Majeed Asmaa Mohammed Noori |
| author_facet | Alaa Abdullah Majeed Asmaa Mohammed Noori |
| author_sort | Alaa Abdullah Majeed |
| collection | DOAJ |
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A new ligand (5-(2-benzamido-N-methylacetamido)-4-((3,4,5-trimethoxycyclohexa-1,3-dien-1-yl) methyl) pyrimidine-2-yl) amino)boric acid was synthesized by the reaction of trimethoprim amide derivative with boric acid, as well as its metal complexes with Co (II), Ni (II), and Pt (IV). Spectral methods such as Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, and proton nuclear magnetic resonance (1H-NMR) spectra, along with thermal analysis (TG/DTA), elemental analysis (CHN), and melting point, were used to characterize the synthesized compounds. This study conducted additional examinations for metal complexes, including molar conductivity, magnetic susceptibility, chloride, and metal content. All synthesized complexes have octahedral geometry; cobalt and nickel complexes are nonelectrolytes, while platinum complexes are electrolytic. This study tested all the synthesized compounds as antibacterial and antifungal agents against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albican. Additionally, this study tested the new ligand and its platinum complexes as anticancer agents against adenocarcinoma human cells (A549). Thus study have achieved positive outcomes for every complex's antibacterial, antifungal, and anticancer properties.
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| format | Article |
| id | doaj-art-5bb2d9d798e24c7a8f36d3318bbd6ef6 |
| institution | Kabale University |
| issn | 1609-4042 2521-3407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj-art-5bb2d9d798e24c7a8f36d3318bbd6ef62025-01-22T01:21:09ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072025-01-0138110.30526/38.1.3418New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer ActivityAlaa Abdullah Majeed0https://orcid.org/0009-0005-4005-9896Asmaa Mohammed Noori1https://orcid.org/0000-0002-2877-5663Department of Chemistry, College of Sciences, University of Baghdad, Baghdad, IraqDepartment of Chemistry, College of Sciences, University of Baghdad A new ligand (5-(2-benzamido-N-methylacetamido)-4-((3,4,5-trimethoxycyclohexa-1,3-dien-1-yl) methyl) pyrimidine-2-yl) amino)boric acid was synthesized by the reaction of trimethoprim amide derivative with boric acid, as well as its metal complexes with Co (II), Ni (II), and Pt (IV). Spectral methods such as Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, and proton nuclear magnetic resonance (1H-NMR) spectra, along with thermal analysis (TG/DTA), elemental analysis (CHN), and melting point, were used to characterize the synthesized compounds. This study conducted additional examinations for metal complexes, including molar conductivity, magnetic susceptibility, chloride, and metal content. All synthesized complexes have octahedral geometry; cobalt and nickel complexes are nonelectrolytes, while platinum complexes are electrolytic. This study tested all the synthesized compounds as antibacterial and antifungal agents against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albican. Additionally, this study tested the new ligand and its platinum complexes as anticancer agents against adenocarcinoma human cells (A549). Thus study have achieved positive outcomes for every complex's antibacterial, antifungal, and anticancer properties. https://jih.uobaghdad.edu.iq/index.php/j/article/view/3418Trimethoprimboric acidcobalt complexnickel complexplatinum complex |
| spellingShingle | Alaa Abdullah Majeed Asmaa Mohammed Noori New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer Activity Ibn Al-Haitham Journal for Pure and Applied Sciences Trimethoprim boric acid cobalt complex nickel complex platinum complex |
| title | New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer Activity |
| title_full | New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer Activity |
| title_fullStr | New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer Activity |
| title_full_unstemmed | New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer Activity |
| title_short | New Boric Acid Derivative with Some of Its Complexes and Study the Biological and Anticancer Activity |
| title_sort | new boric acid derivative with some of its complexes and study the biological and anticancer activity |
| topic | Trimethoprim boric acid cobalt complex nickel complex platinum complex |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3418 |
| work_keys_str_mv | AT alaaabdullahmajeed newboricacidderivativewithsomeofitscomplexesandstudythebiologicalandanticanceractivity AT asmaamohammednoori newboricacidderivativewithsomeofitscomplexesandstudythebiologicalandanticanceractivity |