Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three Cases
Although nephroblastoma is the commonest renal tumor of childhood, it is rare in adults. In cases of predominantly epithelial type occurring in adulthood, it might be difficult to distinguish it from papillary renal cell carcinoma and metanephric adenoma. Here, we report three cases of adult epithel...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2013/675875 |
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| author | Shiho Watanabe Hiroshi Naganuma Michio Shimizu Satoshi Ota Shin-ichi Murata Naoki Nihei Jun Matsushima Shuji Mikami Naoto Kuroda Yoji Nagashima Yukio Nakatani |
| author_facet | Shiho Watanabe Hiroshi Naganuma Michio Shimizu Satoshi Ota Shin-ichi Murata Naoki Nihei Jun Matsushima Shuji Mikami Naoto Kuroda Yoji Nagashima Yukio Nakatani |
| author_sort | Shiho Watanabe |
| collection | DOAJ |
| description | Although nephroblastoma is the commonest renal tumor of childhood, it is rare in adults. In cases of predominantly epithelial type occurring in adulthood, it might be difficult to distinguish it from papillary renal cell carcinoma and metanephric adenoma. Here, we report three cases of adult epithelial nephroblastoma in 24-, 76-, and 21-year-old females. Histologically, the tumors were composed of papillotubular architectures of small and uniform tumor cells with high nucleocytoplasmic ratio without blastemal element. Immunohistochemically, the tumor cells were positive for WT-1 and CD57 but negative for AMACR, which was helpful to exclude the possibility of papillary renal cell carcinoma. Metanephric adenoma is a benign tumor, which can be distinguished by the observation of the cellular atypism and growth pattern. However, nephroblastoma with predominant epithelial element mimics the malignant counterpart of metanephric adenoma, that is, “metanephric adenocarcinoma.” |
| format | Article |
| id | doaj-art-5bac1666eaf14389b9e320ce0b71ca48 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-5bac1666eaf14389b9e320ce0b71ca482025-02-03T05:58:17ZengWileyCase Reports in Pathology2090-67812090-679X2013-01-01201310.1155/2013/675875675875Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three CasesShiho Watanabe0Hiroshi Naganuma1Michio Shimizu2Satoshi Ota3Shin-ichi Murata4Naoki Nihei5Jun Matsushima6Shuji Mikami7Naoto Kuroda8Yoji Nagashima9Yukio Nakatani10Departments of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDivisions of Surgical Pathology, Sendai City Hospital, Sendai 984-8501, JapanDepartment of Pathology, Saitama Medical University International Medical Center, Saitama 350-1298, JapanDepartments of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Human Pathology, Wakayama Prefectural Medical College, Wakayama 641-8509, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Pathology, Saitama Medical University International Medical Center, Saitama 350-1298, JapanDivision of Diagnostic Pathology, Keio University Hospital, Tokyo 160-8582, JapanDivision of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780-8562, JapanDepartment of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, JapanDepartments of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanAlthough nephroblastoma is the commonest renal tumor of childhood, it is rare in adults. In cases of predominantly epithelial type occurring in adulthood, it might be difficult to distinguish it from papillary renal cell carcinoma and metanephric adenoma. Here, we report three cases of adult epithelial nephroblastoma in 24-, 76-, and 21-year-old females. Histologically, the tumors were composed of papillotubular architectures of small and uniform tumor cells with high nucleocytoplasmic ratio without blastemal element. Immunohistochemically, the tumor cells were positive for WT-1 and CD57 but negative for AMACR, which was helpful to exclude the possibility of papillary renal cell carcinoma. Metanephric adenoma is a benign tumor, which can be distinguished by the observation of the cellular atypism and growth pattern. However, nephroblastoma with predominant epithelial element mimics the malignant counterpart of metanephric adenoma, that is, “metanephric adenocarcinoma.”http://dx.doi.org/10.1155/2013/675875 |
| spellingShingle | Shiho Watanabe Hiroshi Naganuma Michio Shimizu Satoshi Ota Shin-ichi Murata Naoki Nihei Jun Matsushima Shuji Mikami Naoto Kuroda Yoji Nagashima Yukio Nakatani Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three Cases Case Reports in Pathology |
| title | Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three Cases |
| title_full | Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three Cases |
| title_fullStr | Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three Cases |
| title_full_unstemmed | Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three Cases |
| title_short | Adult Nephroblastoma with Predominant Epithelial Component: A Differential Diagnostic Candidate of Papillary Renal Cell Carcinoma and Metanephric Adenoma—Report of Three Cases |
| title_sort | adult nephroblastoma with predominant epithelial component a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma report of three cases |
| url | http://dx.doi.org/10.1155/2013/675875 |
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