Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly
Background. The aging population is increasingly susceptible to cardiovascular disease (CVD). Visit-to-visit variability in glucose and lipid levels both contributed to CVD risk independent of their mean values. However, whether variability in the triglyceride-glucose (TyG) index is a risk factor fo...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/5125884 |
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| author | Fei Chen Ying Pan Ziqing Liu Rong Huang Jing Wang Jian Shao Yaqin Gong Xiyi Sun Xiaobo Jiang Weihao Wang Zhaoqiang Li Shao Zhong Qi Pan Kaixin Zhou |
| author_facet | Fei Chen Ying Pan Ziqing Liu Rong Huang Jing Wang Jian Shao Yaqin Gong Xiyi Sun Xiaobo Jiang Weihao Wang Zhaoqiang Li Shao Zhong Qi Pan Kaixin Zhou |
| author_sort | Fei Chen |
| collection | DOAJ |
| description | Background. The aging population is increasingly susceptible to cardiovascular disease (CVD). Visit-to-visit variability in glucose and lipid levels both contributed to CVD risk independent of their mean values. However, whether variability in the triglyceride-glucose (TyG) index is a risk factor for CVD remains unknown. Research Design and Methods. In this retrospective study of electronic health records, 27,520 participants aged over 60 years were enrolled. The visit-to-visit variability of TyG index was calculated from annual health examination data and defined as average real variability (ARV), standard deviation (SD), or the coefficient of variability (CV). CVD events were identified from the chronic disease registry or follow-up database and included myocardial infarction, angina, coronary, and stroke. Multivariate Cox regression was used to examine the correlation between TyG variability and incident CVD. Results. Over a median follow-up of 6.2 years, there were 2,178 CVD events. When participants were divided into four quartiles according to their TyG variability, after adjusting for established CVD risk factors, subjects in the top quartile had (HR = 1.18, 95% CI 1.05–1.34, P=0.005) significantly higher CVD risk than those in the bottom quartile. The association remained significant in overweight individuals or those without diabetes (P<0.005 and P<0.01, respectively). Conclusions. High variability in TyG was significantly associated with elevated CVD risk in the elderly, independent of average TyG and other risk factors. Close monitoring variability in TyG might be informative to identify old individuals at high risk of CVD. |
| format | Article |
| id | doaj-art-5ba23c2db6b94dc4847989523d1d6312 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5ba23c2db6b94dc4847989523d1d63122025-02-03T01:19:58ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/5125884Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the ElderlyFei Chen0Ying Pan1Ziqing Liu2Rong Huang3Jing Wang4Jian Shao5Yaqin Gong6Xiyi Sun7Xiaobo Jiang8Weihao Wang9Zhaoqiang Li10Shao Zhong11Qi Pan12Kaixin Zhou13College of Life SciencesDepartment of EndocrinologyCollege of Life SciencesGuangzhou LaboratoryCollege of Life SciencesCollege of Life SciencesDepartment of Medical InformaticsDepartment of Medical InformaticsZhenChuan Community Health Service CenterDepartment of EndocrinologyGuangzhou LaboratoryDepartment of EndocrinologyDepartment of EndocrinologyCollege of Life SciencesBackground. The aging population is increasingly susceptible to cardiovascular disease (CVD). Visit-to-visit variability in glucose and lipid levels both contributed to CVD risk independent of their mean values. However, whether variability in the triglyceride-glucose (TyG) index is a risk factor for CVD remains unknown. Research Design and Methods. In this retrospective study of electronic health records, 27,520 participants aged over 60 years were enrolled. The visit-to-visit variability of TyG index was calculated from annual health examination data and defined as average real variability (ARV), standard deviation (SD), or the coefficient of variability (CV). CVD events were identified from the chronic disease registry or follow-up database and included myocardial infarction, angina, coronary, and stroke. Multivariate Cox regression was used to examine the correlation between TyG variability and incident CVD. Results. Over a median follow-up of 6.2 years, there were 2,178 CVD events. When participants were divided into four quartiles according to their TyG variability, after adjusting for established CVD risk factors, subjects in the top quartile had (HR = 1.18, 95% CI 1.05–1.34, P=0.005) significantly higher CVD risk than those in the bottom quartile. The association remained significant in overweight individuals or those without diabetes (P<0.005 and P<0.01, respectively). Conclusions. High variability in TyG was significantly associated with elevated CVD risk in the elderly, independent of average TyG and other risk factors. Close monitoring variability in TyG might be informative to identify old individuals at high risk of CVD.http://dx.doi.org/10.1155/2022/5125884 |
| spellingShingle | Fei Chen Ying Pan Ziqing Liu Rong Huang Jing Wang Jian Shao Yaqin Gong Xiyi Sun Xiaobo Jiang Weihao Wang Zhaoqiang Li Shao Zhong Qi Pan Kaixin Zhou Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly International Journal of Endocrinology |
| title | Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly |
| title_full | Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly |
| title_fullStr | Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly |
| title_full_unstemmed | Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly |
| title_short | Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly |
| title_sort | impact of visit to visit triglyceride glucose index variability on the risk of cardiovascular disease in the elderly |
| url | http://dx.doi.org/10.1155/2022/5125884 |
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