Potential of Black Phosphorus in Immune-Based Therapeutic Strategies
Black phosphorus (BP) consists of phosphorus atoms, an essential element of bone and nucleic acid, which covalently bonds to three adjacent phosphorus atoms to form a puckered bilayer structure. With its anisotropy, band gap, biodegradability, and biocompatibility properties, BP is considered promis...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2022/3790097 |
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| _version_ | 1832551186263179264 |
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| author | Wenjuan Dong Hu Wang Hailin Liu Chunqiao Zhou Xuelin Zhang Song Wang Lin He |
| author_facet | Wenjuan Dong Hu Wang Hailin Liu Chunqiao Zhou Xuelin Zhang Song Wang Lin He |
| author_sort | Wenjuan Dong |
| collection | DOAJ |
| description | Black phosphorus (BP) consists of phosphorus atoms, an essential element of bone and nucleic acid, which covalently bonds to three adjacent phosphorus atoms to form a puckered bilayer structure. With its anisotropy, band gap, biodegradability, and biocompatibility properties, BP is considered promising for cancer therapy. For example, BP under irradiation can convert near-infrared (NIR) light into heat and reactive oxygen species (ROS) to damage cancer cells, called photothermal therapy (PTT) and photodynamic therapy (PDT). Compared with PTT and PDT, the novel techniques of sonodynamic therapy (SDT) and photoacoustic therapy (PAT) exhibit amplified ROS generation and precise photoacoustic-shockwaves to enhance anticancer effect when BP receives ultrasound or NIR irradiation. Based on the prospective phototherapy, BP with irradiation can cause a “double-kill” to tumor cells, involving tumor-structure damage induced by heat, ROS, and shockwaves and a subsequent anticancer immune response induced by in situ vaccines construction in tumor site, which is referred to as photoimmunotherapy (PIT). In conclusion, BP shows promise in natural antitumor biological activity, biological imaging, drug delivery, PTT/PDT/SDT/PAT/PIT, nanovaccines, nanoadjuvants, and combination immunotherapy regimens. |
| format | Article |
| id | doaj-art-5ba0f259b9a44ac5a4e6634804a1ea89 |
| institution | Kabale University |
| issn | 1687-479X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-5ba0f259b9a44ac5a4e6634804a1ea892025-02-03T06:04:49ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/3790097Potential of Black Phosphorus in Immune-Based Therapeutic StrategiesWenjuan Dong0Hu Wang1Hailin Liu2Chunqiao Zhou3Xuelin Zhang4Song Wang5Lin He6Department of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyBlack phosphorus (BP) consists of phosphorus atoms, an essential element of bone and nucleic acid, which covalently bonds to three adjacent phosphorus atoms to form a puckered bilayer structure. With its anisotropy, band gap, biodegradability, and biocompatibility properties, BP is considered promising for cancer therapy. For example, BP under irradiation can convert near-infrared (NIR) light into heat and reactive oxygen species (ROS) to damage cancer cells, called photothermal therapy (PTT) and photodynamic therapy (PDT). Compared with PTT and PDT, the novel techniques of sonodynamic therapy (SDT) and photoacoustic therapy (PAT) exhibit amplified ROS generation and precise photoacoustic-shockwaves to enhance anticancer effect when BP receives ultrasound or NIR irradiation. Based on the prospective phototherapy, BP with irradiation can cause a “double-kill” to tumor cells, involving tumor-structure damage induced by heat, ROS, and shockwaves and a subsequent anticancer immune response induced by in situ vaccines construction in tumor site, which is referred to as photoimmunotherapy (PIT). In conclusion, BP shows promise in natural antitumor biological activity, biological imaging, drug delivery, PTT/PDT/SDT/PAT/PIT, nanovaccines, nanoadjuvants, and combination immunotherapy regimens.http://dx.doi.org/10.1155/2022/3790097 |
| spellingShingle | Wenjuan Dong Hu Wang Hailin Liu Chunqiao Zhou Xuelin Zhang Song Wang Lin He Potential of Black Phosphorus in Immune-Based Therapeutic Strategies Bioinorganic Chemistry and Applications |
| title | Potential of Black Phosphorus in Immune-Based Therapeutic Strategies |
| title_full | Potential of Black Phosphorus in Immune-Based Therapeutic Strategies |
| title_fullStr | Potential of Black Phosphorus in Immune-Based Therapeutic Strategies |
| title_full_unstemmed | Potential of Black Phosphorus in Immune-Based Therapeutic Strategies |
| title_short | Potential of Black Phosphorus in Immune-Based Therapeutic Strategies |
| title_sort | potential of black phosphorus in immune based therapeutic strategies |
| url | http://dx.doi.org/10.1155/2022/3790097 |
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