The association between the oral microbiome and hypertension: a systematic review
Background This study systematically reviewed the available evidence regarding the potential association between oral microbiota and hypertension.Methods A comprehensive search of online databases was conducted by two independent investigators for all relevant articles. All observational studies tha...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2025.2459919 |
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| author | Sadeq Ali Al-Maweri Abeer A. Al-Mashraqi Gamilah Al-Qadhi Nezar Al-Hebshi Raidan Ba-Hattab |
| author_facet | Sadeq Ali Al-Maweri Abeer A. Al-Mashraqi Gamilah Al-Qadhi Nezar Al-Hebshi Raidan Ba-Hattab |
| author_sort | Sadeq Ali Al-Maweri |
| collection | DOAJ |
| description | Background This study systematically reviewed the available evidence regarding the potential association between oral microbiota and hypertension.Methods A comprehensive search of online databases was conducted by two independent investigators for all relevant articles. All observational studies that assessed the association between oral microbiota and hypertension were included. Quality appraisal was conducted using the NOS tool.Results A total of 17 studies comprising 6007 subjects were included. The studies varied with respect to sample type and microbial analysis method. All studies, except one, found significant differences in microbial composition between hypertensive and normotensive subjects. However, there were substantial inconsistencies regarding the specific differences identified. Still, a few taxa were repeatedly found enriched in hypertension including Aggregatibacter, Kingella, Lautropia, and Leptotrachia besides the red complex periodontal pathogens. When considering only studies that controlled for false discovery rates and confounders, Atopobium, Prevotella, and Veillonella were identified as consistently associated with hypertension.Conclusion There are significant differences in the oral microbiome between hypertensive and normotensive subjects. Despite the heterogeneity between the included studies, a subset of microbial taxa seems to be consistently enriched in hypertension. Further studies are highly recommended to explore this association.Registration PROSPERO database (ID: CRD42023495005). |
| format | Article |
| id | doaj-art-5ba02625649d48139896d9ab0a42def4 |
| institution | Kabale University |
| issn | 2000-2297 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-5ba02625649d48139896d9ab0a42def42025-02-02T08:28:01ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972025-12-0117110.1080/20002297.2025.2459919The association between the oral microbiome and hypertension: a systematic reviewSadeq Ali Al-Maweri0Abeer A. Al-Mashraqi1Gamilah Al-Qadhi2Nezar Al-Hebshi3Raidan Ba-Hattab4College of Dental Medicine, QU Health, Qatar University, Doha, QatarCollege of Dental Medicine, QU Health, Qatar University, Doha, QatarDepartment of Basic Dental Sciences, Faculty of Dentistry, University of Science and Technology, Aden, YemenOral Microbiome Research Laboratory, Department of Oral Health Sciences, Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, PA, USACollege of Dental Medicine, QU Health, Qatar University, Doha, QatarBackground This study systematically reviewed the available evidence regarding the potential association between oral microbiota and hypertension.Methods A comprehensive search of online databases was conducted by two independent investigators for all relevant articles. All observational studies that assessed the association between oral microbiota and hypertension were included. Quality appraisal was conducted using the NOS tool.Results A total of 17 studies comprising 6007 subjects were included. The studies varied with respect to sample type and microbial analysis method. All studies, except one, found significant differences in microbial composition between hypertensive and normotensive subjects. However, there were substantial inconsistencies regarding the specific differences identified. Still, a few taxa were repeatedly found enriched in hypertension including Aggregatibacter, Kingella, Lautropia, and Leptotrachia besides the red complex periodontal pathogens. When considering only studies that controlled for false discovery rates and confounders, Atopobium, Prevotella, and Veillonella were identified as consistently associated with hypertension.Conclusion There are significant differences in the oral microbiome between hypertensive and normotensive subjects. Despite the heterogeneity between the included studies, a subset of microbial taxa seems to be consistently enriched in hypertension. Further studies are highly recommended to explore this association.Registration PROSPERO database (ID: CRD42023495005).https://www.tandfonline.com/doi/10.1080/20002297.2025.2459919Oral microbiotadysbiosishypertensionblood pressureassociationdysbiosis |
| spellingShingle | Sadeq Ali Al-Maweri Abeer A. Al-Mashraqi Gamilah Al-Qadhi Nezar Al-Hebshi Raidan Ba-Hattab The association between the oral microbiome and hypertension: a systematic review Journal of Oral Microbiology Oral microbiota dysbiosis hypertension blood pressure association dysbiosis |
| title | The association between the oral microbiome and hypertension: a systematic review |
| title_full | The association between the oral microbiome and hypertension: a systematic review |
| title_fullStr | The association between the oral microbiome and hypertension: a systematic review |
| title_full_unstemmed | The association between the oral microbiome and hypertension: a systematic review |
| title_short | The association between the oral microbiome and hypertension: a systematic review |
| title_sort | association between the oral microbiome and hypertension a systematic review |
| topic | Oral microbiota dysbiosis hypertension blood pressure association dysbiosis |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2025.2459919 |
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