Intricating connections: the role of ferroptosis in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease with multiple tissue damage. However, the pathology remains elusive, and effective treatments are lacking. Multiple types of programmed cell death (PCD) implicated in SLE progression have recently been identified. Al...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534926/full |
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| author | Guowang Zhao Xinghai Li Ying Zhang Ying Zhang Xingzi Wang Li Deng Juan Xu Shumei Jin Zan Zuo Zan Zuo Linting Xun Linting Xun Mei Luo Mei Luo Fan Yang Jialong Qi Jialong Qi Jialong Qi Jialong Qi Ping Fu |
| author_facet | Guowang Zhao Xinghai Li Ying Zhang Ying Zhang Xingzi Wang Li Deng Juan Xu Shumei Jin Zan Zuo Zan Zuo Linting Xun Linting Xun Mei Luo Mei Luo Fan Yang Jialong Qi Jialong Qi Jialong Qi Jialong Qi Ping Fu |
| author_sort | Guowang Zhao |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease with multiple tissue damage. However, the pathology remains elusive, and effective treatments are lacking. Multiple types of programmed cell death (PCD) implicated in SLE progression have recently been identified. Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. Therefore, this review elucidates the potential intricate relationship between SLE and ferroptosis to provide a reliable theoretical basis for further research on ferroptosis in the pathogenesis of SLE. |
| format | Article |
| id | doaj-art-5ba021a739944cf7b935d83c22c0c966 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-5ba021a739944cf7b935d83c22c0c9662025-02-04T06:32:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15349261534926Intricating connections: the role of ferroptosis in systemic lupus erythematosusGuowang Zhao0Xinghai Li1Ying Zhang2Ying Zhang3Xingzi Wang4Li Deng5Juan Xu6Shumei Jin7Zan Zuo8Zan Zuo9Linting Xun10Linting Xun11Mei Luo12Mei Luo13Fan Yang14Jialong Qi15Jialong Qi16Jialong Qi17Jialong Qi18Ping Fu19Department of Rheumatology and Clinical Immunology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Minimal Invasive Intervention Radiology, Ganzhou People’s Hospital, Ganzhou, Jiangxi, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, Yunnan, ChinaDepartment of Nephrology, Yueyang Central Hospital, Yueyang, Hunan, ChinaDepartment of Internal Medicine, Community Health Service Station of Dian Mian Avenue, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Institute of Food and Drug Supervision and Control, Medical Products Administration of Yunnan Province, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Provincial Key Laboratory of Clinical Virology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China0Yunnan Provincial Key Laboratory of Birth Defects and Genetic Diseases, First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Rheumatology and Clinical Immunology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaSystemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease with multiple tissue damage. However, the pathology remains elusive, and effective treatments are lacking. Multiple types of programmed cell death (PCD) implicated in SLE progression have recently been identified. Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. Therefore, this review elucidates the potential intricate relationship between SLE and ferroptosis to provide a reliable theoretical basis for further research on ferroptosis in the pathogenesis of SLE.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534926/fullsystemic lupus erythematosus (SLE)ferroptosisinterferons (IFNs)mitochondrialdamage-associated molecular patterns (DAMPs) |
| spellingShingle | Guowang Zhao Xinghai Li Ying Zhang Ying Zhang Xingzi Wang Li Deng Juan Xu Shumei Jin Zan Zuo Zan Zuo Linting Xun Linting Xun Mei Luo Mei Luo Fan Yang Jialong Qi Jialong Qi Jialong Qi Jialong Qi Ping Fu Intricating connections: the role of ferroptosis in systemic lupus erythematosus Frontiers in Immunology systemic lupus erythematosus (SLE) ferroptosis interferons (IFNs) mitochondrial damage-associated molecular patterns (DAMPs) |
| title | Intricating connections: the role of ferroptosis in systemic lupus erythematosus |
| title_full | Intricating connections: the role of ferroptosis in systemic lupus erythematosus |
| title_fullStr | Intricating connections: the role of ferroptosis in systemic lupus erythematosus |
| title_full_unstemmed | Intricating connections: the role of ferroptosis in systemic lupus erythematosus |
| title_short | Intricating connections: the role of ferroptosis in systemic lupus erythematosus |
| title_sort | intricating connections the role of ferroptosis in systemic lupus erythematosus |
| topic | systemic lupus erythematosus (SLE) ferroptosis interferons (IFNs) mitochondrial damage-associated molecular patterns (DAMPs) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534926/full |
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