Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis
PurposeThe purpose of this current study was to find out whether human immunodeficiency virus (HIV) affected overall survival (OS) of colorectal cancer (CRC) patients after surgery.MethodsPubMed, Embase, the Cochrane Library, and CNKI were searched from inception to March 27, 2023 to find eligible s...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1440105/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582947741368320 |
|---|---|
| author | Wen-Wen Yang Wen-Wen Yang Xiong Zhou Gan He |
| author_facet | Wen-Wen Yang Wen-Wen Yang Xiong Zhou Gan He |
| author_sort | Wen-Wen Yang |
| collection | DOAJ |
| description | PurposeThe purpose of this current study was to find out whether human immunodeficiency virus (HIV) affected overall survival (OS) of colorectal cancer (CRC) patients after surgery.MethodsPubMed, Embase, the Cochrane Library, and CNKI were searched from inception to March 27, 2023 to find eligible studies. Eligible studies included CRC patients grouped by HIV status (HIV-positive and HIV-negative). Stata SE 16 was used for data analysis.ResultsA total of eight studies involving 2180 patients were enrolled in this study. After data analysis, there were significant differences in sex (OR=0.69, 95% CI=0.49 to 0.98, I2 = 22.6%, P=0.04<0.1), tumor grade (OR=6.61, 95% CI=2.36 to 18.49, I2 = 0.00%, P=0.00<0.1), and tumor location (OR=2.19, 95% CI=1.74 to 2.77, I2 = 0.04%, P=0.00<0.1) between the HIV and non-HIV groups. Furthermore, we found that HIV was associated with worse OS in CRC patients after surgery (HR=3.12, 95% CI=2.07 to 4.69, I2 = 52.51%, P=0.00<0.1).ConclusionThis study highlights that HIV is associated with significantly poorer OS in CRC patients after surgery, emphasizing the need for tailored postoperative management strategies for this vulnerable population. Future research should explore underlying mechanisms and potential interventions to improve outcomes for HIV-positive CRC patients. |
| format | Article |
| id | doaj-art-5b87146bd65a42efad2efba01f192eb1 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5b87146bd65a42efad2efba01f192eb12025-01-29T05:21:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.14401051440105Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysisWen-Wen Yang0Wen-Wen Yang1Xiong Zhou2Gan He3Department of Ophthalmology, Chongqing University Center Hospital, Chongqing Emergency Medical Center, Chongqing Fourth People’s Hospital, Chongqing, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gastrointestinal Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gastrointestinal Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaPurposeThe purpose of this current study was to find out whether human immunodeficiency virus (HIV) affected overall survival (OS) of colorectal cancer (CRC) patients after surgery.MethodsPubMed, Embase, the Cochrane Library, and CNKI were searched from inception to March 27, 2023 to find eligible studies. Eligible studies included CRC patients grouped by HIV status (HIV-positive and HIV-negative). Stata SE 16 was used for data analysis.ResultsA total of eight studies involving 2180 patients were enrolled in this study. After data analysis, there were significant differences in sex (OR=0.69, 95% CI=0.49 to 0.98, I2 = 22.6%, P=0.04<0.1), tumor grade (OR=6.61, 95% CI=2.36 to 18.49, I2 = 0.00%, P=0.00<0.1), and tumor location (OR=2.19, 95% CI=1.74 to 2.77, I2 = 0.04%, P=0.00<0.1) between the HIV and non-HIV groups. Furthermore, we found that HIV was associated with worse OS in CRC patients after surgery (HR=3.12, 95% CI=2.07 to 4.69, I2 = 52.51%, P=0.00<0.1).ConclusionThis study highlights that HIV is associated with significantly poorer OS in CRC patients after surgery, emphasizing the need for tailored postoperative management strategies for this vulnerable population. Future research should explore underlying mechanisms and potential interventions to improve outcomes for HIV-positive CRC patients.https://www.frontiersin.org/articles/10.3389/fonc.2025.1440105/fullHIVcolorectal cancersurgeryoverall survivalinfection |
| spellingShingle | Wen-Wen Yang Wen-Wen Yang Xiong Zhou Gan He Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis Frontiers in Oncology HIV colorectal cancer surgery overall survival infection |
| title | Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis |
| title_full | Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis |
| title_fullStr | Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis |
| title_full_unstemmed | Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis |
| title_short | Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis |
| title_sort | patients with colorectal cancer combined with hiv had a worse overall survival after surgery a meta analysis |
| topic | HIV colorectal cancer surgery overall survival infection |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1440105/full |
| work_keys_str_mv | AT wenwenyang patientswithcolorectalcancercombinedwithhivhadaworseoverallsurvivalaftersurgeryametaanalysis AT wenwenyang patientswithcolorectalcancercombinedwithhivhadaworseoverallsurvivalaftersurgeryametaanalysis AT xiongzhou patientswithcolorectalcancercombinedwithhivhadaworseoverallsurvivalaftersurgeryametaanalysis AT ganhe patientswithcolorectalcancercombinedwithhivhadaworseoverallsurvivalaftersurgeryametaanalysis |