Nanoparticles assisted drug delivery for effective management of Glioblastoma
Glioblastoma multiforme (GBM) is one of the most aggressive forms of primary brain tumor with a dire prognosis due to its heterogeneity, invasive nature, and resistance to conventional therapies. Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are ofte...
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Elsevier
2025-01-01
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| Series: | Next Nanotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949829525000063 |
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| author | Mansi Damani Nagesh Nilawar Munira Momin Raghumani Singh Ningthoujham Tabassum Khan |
| author_facet | Mansi Damani Nagesh Nilawar Munira Momin Raghumani Singh Ningthoujham Tabassum Khan |
| author_sort | Mansi Damani |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is one of the most aggressive forms of primary brain tumor with a dire prognosis due to its heterogeneity, invasive nature, and resistance to conventional therapies. Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are often limited by the ability of the tumor to circumvent therapeutic effects and by the physiological barriers that restrict drug delivery to the brain parenchyma. Specifically, the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB) impede the effective concentration of therapeutic agents within the brain, posing a significant challenge in treating GBM. The primary focus of current research has pivoted towards nanotechnology to address these limitations. Due to their size, surface modifications, and capability to encapsulate drugs, nanocarriers like polymeric, metallic, and lipid nanoparticles have shown potential in enhancing the penetration of anticancer agents across the BBB and BBTB, thus increasing treatment efficacy and minimizing general toxicity. Moreover, lipid-based nanoparticles, such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), offer advantages in drug encapsulation, stability, and controlled release metal nanoparticles, including gold and silver nanoparticles, provide unique properties for imaging and photothermal therapy, potentially augmenting the efficacy of conventional treatments. This review elucidates the mechanisms by which nanocarriers cross the BBB and BBTB, emphasizing the importance of physicochemical properties such as size, charge, and surface functionality. The integration of nanotechnology in GBM treatment highlights the potential for nanoparticles to revolutionize drug delivery systems, overcoming the inherent challenges posed by the BBB and the tumor microenvironment. The promise of nanomedicine advances in this field could lead to more effective therapeutic strategies, significantly impacting patient outcomes in GBM management. |
| format | Article |
| id | doaj-art-5b82a86b60294b40bd304045eea6ae01 |
| institution | Kabale University |
| issn | 2949-8295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Nanotechnology |
| spelling | doaj-art-5b82a86b60294b40bd304045eea6ae012025-02-05T04:32:56ZengElsevierNext Nanotechnology2949-82952025-01-017100137Nanoparticles assisted drug delivery for effective management of GlioblastomaMansi Damani0Nagesh Nilawar1Munira Momin2Raghumani Singh Ningthoujham3Tabassum Khan4Department of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, Mumbai, Maharashtra, IndiaDepartment of Quality Assurance, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, Mumbai, Maharashtra, IndiaDepartment of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, Mumbai, Maharashtra, IndiaChemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai - 400085, IndiaDepartment of Pharmaceutical Chemistry, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, Mumbai, Maharashtra, India; Corresponding author.Glioblastoma multiforme (GBM) is one of the most aggressive forms of primary brain tumor with a dire prognosis due to its heterogeneity, invasive nature, and resistance to conventional therapies. Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are often limited by the ability of the tumor to circumvent therapeutic effects and by the physiological barriers that restrict drug delivery to the brain parenchyma. Specifically, the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB) impede the effective concentration of therapeutic agents within the brain, posing a significant challenge in treating GBM. The primary focus of current research has pivoted towards nanotechnology to address these limitations. Due to their size, surface modifications, and capability to encapsulate drugs, nanocarriers like polymeric, metallic, and lipid nanoparticles have shown potential in enhancing the penetration of anticancer agents across the BBB and BBTB, thus increasing treatment efficacy and minimizing general toxicity. Moreover, lipid-based nanoparticles, such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), offer advantages in drug encapsulation, stability, and controlled release metal nanoparticles, including gold and silver nanoparticles, provide unique properties for imaging and photothermal therapy, potentially augmenting the efficacy of conventional treatments. This review elucidates the mechanisms by which nanocarriers cross the BBB and BBTB, emphasizing the importance of physicochemical properties such as size, charge, and surface functionality. The integration of nanotechnology in GBM treatment highlights the potential for nanoparticles to revolutionize drug delivery systems, overcoming the inherent challenges posed by the BBB and the tumor microenvironment. The promise of nanomedicine advances in this field could lead to more effective therapeutic strategies, significantly impacting patient outcomes in GBM management.http://www.sciencedirect.com/science/article/pii/S2949829525000063Glioblastoma multiformenanotechnologyblood-brain barriernanomedicinedrug deliverycancer |
| spellingShingle | Mansi Damani Nagesh Nilawar Munira Momin Raghumani Singh Ningthoujham Tabassum Khan Nanoparticles assisted drug delivery for effective management of Glioblastoma Next Nanotechnology Glioblastoma multiforme nanotechnology blood-brain barrier nanomedicine drug delivery cancer |
| title | Nanoparticles assisted drug delivery for effective management of Glioblastoma |
| title_full | Nanoparticles assisted drug delivery for effective management of Glioblastoma |
| title_fullStr | Nanoparticles assisted drug delivery for effective management of Glioblastoma |
| title_full_unstemmed | Nanoparticles assisted drug delivery for effective management of Glioblastoma |
| title_short | Nanoparticles assisted drug delivery for effective management of Glioblastoma |
| title_sort | nanoparticles assisted drug delivery for effective management of glioblastoma |
| topic | Glioblastoma multiforme nanotechnology blood-brain barrier nanomedicine drug delivery cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2949829525000063 |
| work_keys_str_mv | AT mansidamani nanoparticlesassisteddrugdeliveryforeffectivemanagementofglioblastoma AT nageshnilawar nanoparticlesassisteddrugdeliveryforeffectivemanagementofglioblastoma AT muniramomin nanoparticlesassisteddrugdeliveryforeffectivemanagementofglioblastoma AT raghumanisinghningthoujham nanoparticlesassisteddrugdeliveryforeffectivemanagementofglioblastoma AT tabassumkhan nanoparticlesassisteddrugdeliveryforeffectivemanagementofglioblastoma |