THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS
Objective: To investigate whether beta catenin and Forkhead box protein P1 (FOXP1) play a role in pathogenesis of polypoid endometriosis (PE).Material and Method: Our study included fifteen cases of PE. Clinical findings were gathered from archived files of relevant clinics and pathology reports. Al...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Istanbul University Press
2024-01-01
|
| Series: | İstanbul Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/6795356AB4CE4BBE95BDE3E9ADC2894F |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849313444186030080 |
|---|---|
| author | Ali Yılmaz Altay Ekrem Yavuz Aysel Bayram Cenk Yaşa Hamdullah Sözen Semen Önder |
| author_facet | Ali Yılmaz Altay Ekrem Yavuz Aysel Bayram Cenk Yaşa Hamdullah Sözen Semen Önder |
| author_sort | Ali Yılmaz Altay |
| collection | DOAJ |
| description | Objective: To investigate whether beta catenin and Forkhead box protein P1 (FOXP1) play a role in pathogenesis of polypoid endometriosis (PE).Material and Method: Our study included fifteen cases of PE. Clinical findings were gathered from archived files of relevant clinics and pathology reports. All glass slides were re-examined for confirmation of the diagnosis and the detection of additional microscopic findings. An immunohistochemical examination was performed using anti beta catenin and FOXP1 antibodies in fifteen cases of PE, and in a control group that contained nine cases of endometrial polyps (EP) and nine cases of conventional ovarian endometriosis (OE).Result: Stromal nuclear beta catenin expression was observed in six cases in PE, five cases in EP and one case in the OE group. Stromal FOXP1 staining in PE and EP was significantly reduced as compared to OE. Five PE and two EP cases showed stromal FOXP1 staining while all the OE cases showed stromal FOXP1 staining. The Stromal FOXP1 staining was statistically significant between PE vs OE (p=0.002) and EP vs OE (p=0.023) cases. There was no difference between PE and the control cases in terms of nuclear beta catenin staining (p=0.69). There was no correlation between these two antibodies and histologic features.Conclusion: The loss of stromal FOXP1 is another biological difference of PE and the overall similarity of expression of FOXP1between PE and EP could be regarded as a contributing factor for polyp formation. |
| format | Article |
| id | doaj-art-5b6813be0dae4c3da28d74273cb2c74f |
| institution | Kabale University |
| issn | 1305-6441 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-5b6813be0dae4c3da28d74273cb2c74f2025-08-20T03:52:47ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412024-01-01871546010.26650/IUITFD.1292132123456THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSISAli Yılmaz Altay0https://orcid.org/0000-0003-4678-2047Ekrem Yavuz1https://orcid.org/0000-0002-3166-0648Aysel Bayram2https://orcid.org/0000-0002-5014-0074Cenk Yaşa3https://orcid.org/0000-0002-7183-1456Hamdullah Sözen4https://orcid.org/0000-0003-1894-1688Semen Önder5https://orcid.org/0000-0002-1384-630Xİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: To investigate whether beta catenin and Forkhead box protein P1 (FOXP1) play a role in pathogenesis of polypoid endometriosis (PE).Material and Method: Our study included fifteen cases of PE. Clinical findings were gathered from archived files of relevant clinics and pathology reports. All glass slides were re-examined for confirmation of the diagnosis and the detection of additional microscopic findings. An immunohistochemical examination was performed using anti beta catenin and FOXP1 antibodies in fifteen cases of PE, and in a control group that contained nine cases of endometrial polyps (EP) and nine cases of conventional ovarian endometriosis (OE).Result: Stromal nuclear beta catenin expression was observed in six cases in PE, five cases in EP and one case in the OE group. Stromal FOXP1 staining in PE and EP was significantly reduced as compared to OE. Five PE and two EP cases showed stromal FOXP1 staining while all the OE cases showed stromal FOXP1 staining. The Stromal FOXP1 staining was statistically significant between PE vs OE (p=0.002) and EP vs OE (p=0.023) cases. There was no difference between PE and the control cases in terms of nuclear beta catenin staining (p=0.69). There was no correlation between these two antibodies and histologic features.Conclusion: The loss of stromal FOXP1 is another biological difference of PE and the overall similarity of expression of FOXP1between PE and EP could be regarded as a contributing factor for polyp formation.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/6795356AB4CE4BBE95BDE3E9ADC2894Fendometriosispolypimmunohistochemistryfoxp1beta-catenin |
| spellingShingle | Ali Yılmaz Altay Ekrem Yavuz Aysel Bayram Cenk Yaşa Hamdullah Sözen Semen Önder THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS İstanbul Tıp Fakültesi Dergisi endometriosis polyp immunohistochemistry foxp1 beta-catenin |
| title | THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS |
| title_full | THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS |
| title_fullStr | THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS |
| title_full_unstemmed | THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS |
| title_short | THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS |
| title_sort | role of beta catenin and foxp1 in the pathogenesis of polypoid endometriosis |
| topic | endometriosis polyp immunohistochemistry foxp1 beta-catenin |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/6795356AB4CE4BBE95BDE3E9ADC2894F |
| work_keys_str_mv | AT aliyılmazaltay theroleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT ekremyavuz theroleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT ayselbayram theroleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT cenkyasa theroleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT hamdullahsozen theroleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT semenonder theroleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT aliyılmazaltay roleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT ekremyavuz roleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT ayselbayram roleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT cenkyasa roleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT hamdullahsozen roleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis AT semenonder roleofbetacateninandfoxp1inthepathogenesisofpolypoidendometriosis |