Chimeric Antigen Receptor (CAR) T Cells Releasing Soluble SLAMF6 Isoform 2 Gain Superior Anti-Cancer Cell Functionality in an Auto-Stimulatory Fashion

Chimeric Antigen Receptor (CAR) T Cells Releasing Soluble SLAMF6 Isoform 2 Gain Superior Anti-Cancer Cell Functionality in an Auto-Stimulatory Fashion

T cells equipped with chimeric antigen receptors (CARs) have evolved into an essential pillar of lymphoma therapy, reaching second-line treatment. In solid cancers, however, a dearth of lasting CAR T cell activation poses the major obstacle to achieving a substantial and durable anti-tumor response....

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Bibliographic Details
Main Authors: Dennis Christoph Harrer, Tim Schlierkamp-Voosen, Markus Barden, Hong Pan, Maria Xydia, Wolfgang Herr, Jan Dörrie, Niels Schaft, Hinrich Abken
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
CAR T cell
adoptive T cell therapy
checkpoint
stimulation
exhaustion
Online Access:https://www.mdpi.com/2073-4409/14/12/901
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