Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics
It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/296167 |
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| _version_ | 1832549934888386560 |
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| author | Yeng F. Her L. James Maher |
| author_facet | Yeng F. Her L. James Maher |
| author_sort | Yeng F. Her |
| collection | DOAJ |
| description | It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor. |
| format | Article |
| id | doaj-art-5b503135afbd40a6a9ff8722fb7af416 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5b503135afbd40a6a9ff8722fb7af4162025-02-03T06:08:16ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/296167296167Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and EpigeneticsYeng F. Her0L. James Maher1Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USAIt is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.http://dx.doi.org/10.1155/2015/296167 |
| spellingShingle | Yeng F. Her L. James Maher Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics International Journal of Endocrinology |
| title | Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics |
| title_full | Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics |
| title_fullStr | Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics |
| title_full_unstemmed | Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics |
| title_short | Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics |
| title_sort | succinate dehydrogenase loss in familial paraganglioma biochemistry genetics and epigenetics |
| url | http://dx.doi.org/10.1155/2015/296167 |
| work_keys_str_mv | AT yengfher succinatedehydrogenaselossinfamilialparagangliomabiochemistrygeneticsandepigenetics AT ljamesmaher succinatedehydrogenaselossinfamilialparagangliomabiochemistrygeneticsandepigenetics |