Effects of early aminophylline therapy on clinical outcomes in premature infants
Background: Aminophylline use and the association between clinical outcomes and therapy timing have been less investigated. The objective of this study was to determine the efficacy of early aminophylline use (within the first two days of life) in premature infants. Method: A retrospective observati...
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Elsevier
2023-05-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957222002522 |
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| author | Yi-Ting Chu Jin-Shuen Chen Yao-Shen Chen Chih-Chieh Yang Chun-Hao Yin Hsiao-Ping Wang Yee-Hsuan Chiou |
| author_facet | Yi-Ting Chu Jin-Shuen Chen Yao-Shen Chen Chih-Chieh Yang Chun-Hao Yin Hsiao-Ping Wang Yee-Hsuan Chiou |
| author_sort | Yi-Ting Chu |
| collection | DOAJ |
| description | Background: Aminophylline use and the association between clinical outcomes and therapy timing have been less investigated. The objective of this study was to determine the efficacy of early aminophylline use (within the first two days of life) in premature infants. Method: A retrospective observational cohort of infants weighing <1500 g and <30 weeks of gestational age at Kaohsiung Veterans General Hospital received aminophylline either within the first two days of life (EA, early aminophylline group), after the third day of life (LA, late aminophylline group), or without aminophylline during the first month of life (WA, without aminophylline group). Demographic data and neonatal clinical outcomes were compared among the three groups. Results: This study included 89 preterm infants (EA = 33, LA = 38, WA = 18). The EA group had a lower incidence of bronchopulmonary dysplasia (BPD) than the WA group (adjusted odds ratio [aOR] = 8.86(1.56–59.32); P = 0.024). Although there was no significant difference in BPD incidence between the EA and LA groups (aOR = 2.66(0.51–13.81), P = 0.244), a trend remained. Birth body weight less than 1000 g was also a significant risk factor for BPD (aOR = 8.86(1.32–47.41), P = 0.014). The duration of mechanical ventilation was shorter in the infants in the EA group compared to the WA group (estimated beta = −11.344(-19.57–3.12); P = 0.008). Conclusion: Early aminophylline administration may be associated with a decreased incidence of BPD in preterm infants. However, the clinical benefits of aminophylline treatment require further investigation. In addition, a birth body weight of less than 1000 g was a crucial risk factor for BPD. |
| format | Article |
| id | doaj-art-5b3da6fe7491492e9eb4e6e8f0ee7387 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-5b3da6fe7491492e9eb4e6e8f0ee73872025-08-20T02:05:13ZengElsevierPediatrics and Neonatology1875-95722023-05-0164328829610.1016/j.pedneo.2022.10.004Effects of early aminophylline therapy on clinical outcomes in premature infantsYi-Ting Chu0Jin-Shuen Chen1Yao-Shen Chen2Chih-Chieh Yang3Chun-Hao Yin4Hsiao-Ping Wang5Yee-Hsuan Chiou6Division of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Administration, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, TaiwanDepartment of Administration, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDivision of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Taiwan; Institute of Health Care Management, National Sun Yat-Sen University, TaiwanDivision of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDivision of Pediatric Nephrology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan; Corresponding author. Division of Pediatric Nephrology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, No. 386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City 813, Taiwan.Background: Aminophylline use and the association between clinical outcomes and therapy timing have been less investigated. The objective of this study was to determine the efficacy of early aminophylline use (within the first two days of life) in premature infants. Method: A retrospective observational cohort of infants weighing <1500 g and <30 weeks of gestational age at Kaohsiung Veterans General Hospital received aminophylline either within the first two days of life (EA, early aminophylline group), after the third day of life (LA, late aminophylline group), or without aminophylline during the first month of life (WA, without aminophylline group). Demographic data and neonatal clinical outcomes were compared among the three groups. Results: This study included 89 preterm infants (EA = 33, LA = 38, WA = 18). The EA group had a lower incidence of bronchopulmonary dysplasia (BPD) than the WA group (adjusted odds ratio [aOR] = 8.86(1.56–59.32); P = 0.024). Although there was no significant difference in BPD incidence between the EA and LA groups (aOR = 2.66(0.51–13.81), P = 0.244), a trend remained. Birth body weight less than 1000 g was also a significant risk factor for BPD (aOR = 8.86(1.32–47.41), P = 0.014). The duration of mechanical ventilation was shorter in the infants in the EA group compared to the WA group (estimated beta = −11.344(-19.57–3.12); P = 0.008). Conclusion: Early aminophylline administration may be associated with a decreased incidence of BPD in preterm infants. However, the clinical benefits of aminophylline treatment require further investigation. In addition, a birth body weight of less than 1000 g was a crucial risk factor for BPD.http://www.sciencedirect.com/science/article/pii/S1875957222002522apneabronchopulmonary dysplasiaprematurityxanthines |
| spellingShingle | Yi-Ting Chu Jin-Shuen Chen Yao-Shen Chen Chih-Chieh Yang Chun-Hao Yin Hsiao-Ping Wang Yee-Hsuan Chiou Effects of early aminophylline therapy on clinical outcomes in premature infants Pediatrics and Neonatology apnea bronchopulmonary dysplasia prematurity xanthines |
| title | Effects of early aminophylline therapy on clinical outcomes in premature infants |
| title_full | Effects of early aminophylline therapy on clinical outcomes in premature infants |
| title_fullStr | Effects of early aminophylline therapy on clinical outcomes in premature infants |
| title_full_unstemmed | Effects of early aminophylline therapy on clinical outcomes in premature infants |
| title_short | Effects of early aminophylline therapy on clinical outcomes in premature infants |
| title_sort | effects of early aminophylline therapy on clinical outcomes in premature infants |
| topic | apnea bronchopulmonary dysplasia prematurity xanthines |
| url | http://www.sciencedirect.com/science/article/pii/S1875957222002522 |
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