Evaluation of toxic effects of benzophenone on histopathology of Labeo rohita
Benzophenone (BP) is an organic ultraviolet (UV) filter widely used in sunscreens and personal care products. This compound enters aquatic ecosystems due to industrialization, wastewater treatment plants (WWTPs), and domestic effluents, poses serious threats to aquatic organisms, and is considered a...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000320 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595398635552768 |
|---|---|
| author | Maham Riaz Sajid Abdullah Mina Jamil Amna Rasheed Urwah Sheikh Maham Fatima Nimra Umer Kaynat Aslam |
| author_facet | Maham Riaz Sajid Abdullah Mina Jamil Amna Rasheed Urwah Sheikh Maham Fatima Nimra Umer Kaynat Aslam |
| author_sort | Maham Riaz |
| collection | DOAJ |
| description | Benzophenone (BP) is an organic ultraviolet (UV) filter widely used in sunscreens and personal care products. This compound enters aquatic ecosystems due to industrialization, wastewater treatment plants (WWTPs), and domestic effluents, poses serious threats to aquatic organisms, and is considered an emerging pollutant. This laboratory-based study assessed the 96-hour (h) median lethal concentrations (LC50) and sub-lethal effects of BP on the histology of the gills and muscles of Labeo rohita. Fish fingerlings of the same weight (48 ± 2 g) and length (5 ± 2 in.) were exposed to gradually increasing concentrations of BP (100 µg/L to 1000 µg/L) and their 96-h LC50 was determined as 612.822 ± 37.38 µg/L. To determine the sub-lethal effects, the fish were exposed to 1/5th of the 96-h LC50 of BP for 35 days (d) to investigate organ-specific responses. The results indicated significant damage to the exposed organs and showed damage in pillar cells and intraluminal debris in gill mucous cells. Moreover, fragmentation of intact muscle structures, intraluminal debris, and vascular necrosis were observed in exposed muscles. In conclusion, these results confirmed the histopathological changes in the gills and muscles of L. rohita caused by BP exposure, thereby confirming its risk to aquatic life. |
| format | Article |
| id | doaj-art-5b39abe274a247df8f76976eeb50f688 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-5b39abe274a247df8f76976eeb50f6882025-01-19T06:25:04ZengElsevierToxicology Reports2214-75002025-06-0114101914Evaluation of toxic effects of benzophenone on histopathology of Labeo rohitaMaham Riaz0Sajid Abdullah1Mina Jamil2Amna Rasheed3Urwah Sheikh4Maham Fatima5Nimra Umer6Kaynat Aslam7Corresponding author.; Department of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife & Fisheries, University of Agriculture, Faisalabad, PakistanBenzophenone (BP) is an organic ultraviolet (UV) filter widely used in sunscreens and personal care products. This compound enters aquatic ecosystems due to industrialization, wastewater treatment plants (WWTPs), and domestic effluents, poses serious threats to aquatic organisms, and is considered an emerging pollutant. This laboratory-based study assessed the 96-hour (h) median lethal concentrations (LC50) and sub-lethal effects of BP on the histology of the gills and muscles of Labeo rohita. Fish fingerlings of the same weight (48 ± 2 g) and length (5 ± 2 in.) were exposed to gradually increasing concentrations of BP (100 µg/L to 1000 µg/L) and their 96-h LC50 was determined as 612.822 ± 37.38 µg/L. To determine the sub-lethal effects, the fish were exposed to 1/5th of the 96-h LC50 of BP for 35 days (d) to investigate organ-specific responses. The results indicated significant damage to the exposed organs and showed damage in pillar cells and intraluminal debris in gill mucous cells. Moreover, fragmentation of intact muscle structures, intraluminal debris, and vascular necrosis were observed in exposed muscles. In conclusion, these results confirmed the histopathological changes in the gills and muscles of L. rohita caused by BP exposure, thereby confirming its risk to aquatic life.http://www.sciencedirect.com/science/article/pii/S2214750025000320HistopathologyBenzophenoneLabeo rohitaUltraviolet filtersChronic toxicity |
| spellingShingle | Maham Riaz Sajid Abdullah Mina Jamil Amna Rasheed Urwah Sheikh Maham Fatima Nimra Umer Kaynat Aslam Evaluation of toxic effects of benzophenone on histopathology of Labeo rohita Toxicology Reports Histopathology Benzophenone Labeo rohita Ultraviolet filters Chronic toxicity |
| title | Evaluation of toxic effects of benzophenone on histopathology of Labeo rohita |
| title_full | Evaluation of toxic effects of benzophenone on histopathology of Labeo rohita |
| title_fullStr | Evaluation of toxic effects of benzophenone on histopathology of Labeo rohita |
| title_full_unstemmed | Evaluation of toxic effects of benzophenone on histopathology of Labeo rohita |
| title_short | Evaluation of toxic effects of benzophenone on histopathology of Labeo rohita |
| title_sort | evaluation of toxic effects of benzophenone on histopathology of labeo rohita |
| topic | Histopathology Benzophenone Labeo rohita Ultraviolet filters Chronic toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000320 |
| work_keys_str_mv | AT mahamriaz evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita AT sajidabdullah evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita AT minajamil evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita AT amnarasheed evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita AT urwahsheikh evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita AT mahamfatima evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita AT nimraumer evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita AT kaynataslam evaluationoftoxiceffectsofbenzophenoneonhistopathologyoflabeorohita |