Temporal dichotomy of neutrophil function in acute liver injury and repair

Temporal dichotomy of neutrophil function in acute liver injury and repair

Background & aims: Acetaminophen (APAP)-induced acute liver injury (APAP-ALI) is the leading cause of acute liver failure-induced death, with host innate immune responses driving outcomes. Neutrophils are activated and increased in APAP-ALI and reported to contribute to liver damage. However...

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Main Authors: Jennifer A. Cartwright, Philippe M.D. Potey, Eilidh Livingstone, Lara Campana, Philip J. Starkey Lewis, Magdalena E.M. Oremek, Naomi N. Gachanja, Giulia Rinaldi, Rhona E. Aird, Tak Yung Man, Anuruddika J. Fernando, Joanna P. Simpson, Natalie Z.M. Homer, Nicole Barth, Melisande Addison, Candice Ashmore-Harris, Maria Elena Candela, Alastair M. Kilpatrick, Matthieu Vermeren, Calum T. Robb, David A. Dorward, Christopher D. Lucas, Stuart J. Forbes, Adriano G. Rossi
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:JHEP Reports
Subjects:
Hepatic
Paracetamol
Acetaminophen
Formylated-peptide-receptor 1
Monocyte
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000941
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