Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1
Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Fiv...
Saved in:
Main Authors: | Huizhen Fan, Chunyan Jiang, Baoyuan Zhong, Jianwen Sheng, Ting Chen, Qingqing Chen, Jingtao Li, Hongchuan Zhao |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2018-01-01
|
Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2018/5408324 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
HMGB1 Localization during Experimental Periodontitis
by: Andressa Vilas Boas Nogueira, et al.
Published: (2014-01-01) -
The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes
by: Yanan Wang, et al.
Published: (2016-01-01) -
Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+ Myeloid-Derived Suppressor Cells Require HMGB1
by: Xiangcai Ruan, et al.
Published: (2015-01-01) -
Association between HMGB1 and COPD: A Systematic Review
by: Sebastiano Gangemi, et al.
Published: (2015-01-01) -
Evaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury
by: Célio Geraldo de Oliveira Gomes, et al.
Published: (2020-01-01)