Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1
Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Fiv...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5408324 |
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| author | Huizhen Fan Chunyan Jiang Baoyuan Zhong Jianwen Sheng Ting Chen Qingqing Chen Jingtao Li Hongchuan Zhao |
| author_facet | Huizhen Fan Chunyan Jiang Baoyuan Zhong Jianwen Sheng Ting Chen Qingqing Chen Jingtao Li Hongchuan Zhao |
| author_sort | Huizhen Fan |
| collection | DOAJ |
| description | Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine’s mechanism. Expression of predicted serum targets were verified in a 1,2-dimethylhydrazine dihydrochloride-induced CRC model rats that were treated with matrine (ip) for 18 weeks. Data show that matrine suppressed CRC growth and decreased previously elevated expression of IL-6, TNF-α, p53, and HMGB1. Matrine may have had a therapeutic effect on CRC via inhibition of HMGB1 signaling, and this occurred through downregulation of IL-6, TNF-α, and HMGB1. |
| format | Article |
| id | doaj-art-5b2e56634b2a4d69a89cca345fdda6e4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5b2e56634b2a4d69a89cca345fdda6e42025-02-03T01:23:43ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/54083245408324Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1Huizhen Fan0Chunyan Jiang1Baoyuan Zhong2Jianwen Sheng3Ting Chen4Qingqing Chen5Jingtao Li6Hongchuan Zhao7Department of Gastroenterology, The People’s Hospital of Yichun City, Yichun, ChinaDepartment of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Beijing, ChinaDepartment of General Surgery, First Affiliated Hospital of Gannan Medical College, Ganzhou, ChinaDepartment of Gastroenterology, The People’s Hospital of Yichun City, Yichun, ChinaDepartment of Gastroenterology, The People’s Hospital of Yichun City, Yichun, ChinaDepartment of Gastroenterology, The People’s Hospital of Yichun City, Yichun, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaMatrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine’s mechanism. Expression of predicted serum targets were verified in a 1,2-dimethylhydrazine dihydrochloride-induced CRC model rats that were treated with matrine (ip) for 18 weeks. Data show that matrine suppressed CRC growth and decreased previously elevated expression of IL-6, TNF-α, p53, and HMGB1. Matrine may have had a therapeutic effect on CRC via inhibition of HMGB1 signaling, and this occurred through downregulation of IL-6, TNF-α, and HMGB1.http://dx.doi.org/10.1155/2018/5408324 |
| spellingShingle | Huizhen Fan Chunyan Jiang Baoyuan Zhong Jianwen Sheng Ting Chen Qingqing Chen Jingtao Li Hongchuan Zhao Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 Journal of Immunology Research |
| title | Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 |
| title_full | Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 |
| title_fullStr | Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 |
| title_full_unstemmed | Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 |
| title_short | Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 |
| title_sort | matrine ameliorates colorectal cancer in rats via inhibition of hmgb1 signaling and downregulation of il 6 tnf α and hmgb1 |
| url | http://dx.doi.org/10.1155/2018/5408324 |
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