A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India
Background: This study aimed to compare the effectiveness of dienogest (DNG) and combined oral contraceptive (COC) pills in alleviating pain among patients with endometriosis in Eastern India. Materials and Methods: A prospective, hospital-based, observational comparative study was conducted at R. G...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | MGM Journal of Medical Sciences |
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| Online Access: | https://doi.org/10.4103/mgmj.mgmj_113_25 |
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| author | Priyanka Kumari Rathindra Nath Ray Sandip Sarkar Sohini Ghosh Dastidar Yogesh Munde |
| author_facet | Priyanka Kumari Rathindra Nath Ray Sandip Sarkar Sohini Ghosh Dastidar Yogesh Munde |
| author_sort | Priyanka Kumari |
| collection | DOAJ |
| description | Background: This study aimed to compare the effectiveness of dienogest (DNG) and combined oral contraceptive (COC) pills in alleviating pain among patients with endometriosis in Eastern India. Materials and Methods: A prospective, hospital-based, observational comparative study was conducted at R. G. Kar Medical College and Hospital in Kolkata, India, from March 2021 to August 2022. The study included two groups: Group A (dienogest 2 mg/day, n = 115) and Group B (combined oral contraceptive pills, Mala-N, n = 115). Pain levels were assessed using the Visual Analog Scale (VAS), and the quality of life (QoL) was evaluated with the Endometriosis Health Profile Questionnaire (EHP-5 PRO) after 3 and 6 months of treatment. Results: The mean age ± standard deviation was 32.57 ± 8.02 years in Group A and 32.89 ± 7.92 years in Group B. After 6 months, Group A showed a significant reduction in pelvic pain (P = 0.001), whereas Group B did not experience a significant improvement (P = 0.55). A significant difference in pain reduction was observed between the two groups after 6 months (P = 0.0001). Both treatments resulted in slight improvements in the quality of life, but the difference between the groups was not statistically significant. Conclusion: Both dienogest and COC pills may assist in managing endometriosis-related pain and enhancing the quality of life, with dienogest showing superior pain relief. These medications appear to be safe and effective options for managing endometriosis. |
| format | Article |
| id | doaj-art-5b143bdecfca4f71bc20ec9de6f7ff8e |
| institution | OA Journals |
| issn | 2347-7946 2347-7962 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MGM Journal of Medical Sciences |
| spelling | doaj-art-5b143bdecfca4f71bc20ec9de6f7ff8e2025-08-20T02:36:46ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622025-04-0112232233010.4103/mgmj.mgmj_113_25A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern IndiaPriyanka KumariRathindra Nath RaySandip SarkarSohini Ghosh DastidarYogesh MundeBackground: This study aimed to compare the effectiveness of dienogest (DNG) and combined oral contraceptive (COC) pills in alleviating pain among patients with endometriosis in Eastern India. Materials and Methods: A prospective, hospital-based, observational comparative study was conducted at R. G. Kar Medical College and Hospital in Kolkata, India, from March 2021 to August 2022. The study included two groups: Group A (dienogest 2 mg/day, n = 115) and Group B (combined oral contraceptive pills, Mala-N, n = 115). Pain levels were assessed using the Visual Analog Scale (VAS), and the quality of life (QoL) was evaluated with the Endometriosis Health Profile Questionnaire (EHP-5 PRO) after 3 and 6 months of treatment. Results: The mean age ± standard deviation was 32.57 ± 8.02 years in Group A and 32.89 ± 7.92 years in Group B. After 6 months, Group A showed a significant reduction in pelvic pain (P = 0.001), whereas Group B did not experience a significant improvement (P = 0.55). A significant difference in pain reduction was observed between the two groups after 6 months (P = 0.0001). Both treatments resulted in slight improvements in the quality of life, but the difference between the groups was not statistically significant. Conclusion: Both dienogest and COC pills may assist in managing endometriosis-related pain and enhancing the quality of life, with dienogest showing superior pain relief. These medications appear to be safe and effective options for managing endometriosis.https://doi.org/10.4103/mgmj.mgmj_113_25dngendometriosisocpspelvic painquality of life |
| spellingShingle | Priyanka Kumari Rathindra Nath Ray Sandip Sarkar Sohini Ghosh Dastidar Yogesh Munde A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India MGM Journal of Medical Sciences dng endometriosis ocps pelvic pain quality of life |
| title | A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India |
| title_full | A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India |
| title_fullStr | A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India |
| title_full_unstemmed | A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India |
| title_short | A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India |
| title_sort | comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in eastern india |
| topic | dng endometriosis ocps pelvic pain quality of life |
| url | https://doi.org/10.4103/mgmj.mgmj_113_25 |
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