Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease
Inflammatory disorders account for a significant percentage of gynecologic diseases, particularly in women of reproductive age. It is known that stem cells have anti-inflammatory and regenerative properties. Based on this, we investigated the effect of intravenous administration of cryopreserved mes...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/2014132 |
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| author | Nataliia Volkova Mariia Yukhta Anatoliy Goltsev |
| author_facet | Nataliia Volkova Mariia Yukhta Anatoliy Goltsev |
| author_sort | Nataliia Volkova |
| collection | DOAJ |
| description | Inflammatory disorders account for a significant percentage of gynecologic diseases, particularly in women of reproductive age. It is known that stem cells have anti-inflammatory and regenerative properties. Based on this, we investigated the effect of intravenous administration of cryopreserved mesenchymal stem cells (cMSCs) of bone marrow on experimental chronic inflammation of the ovaries. The paper shows that on the 21st day after cMSC therapy, leukocyte infiltration of ovaries was slightly relative to the control group without treatment, and the ratio of developing and atretic follicles in the animals with cMSC injection dramatically increased, while in the control, it still remained on the side of atretic forms. The number of apoptotic oocytes after stimulation of superovulation in the control group was significantly higher (85.3 ± 5.2%) than that in the animals with therapy (5.7 ± 0.8%). Relative number of fertilized eggs in the group with cMSC therapy was higher by 40% compare to that in the control. Pregnancy rate in natural estrous cycle after cell administration increased by 20%, and average number of litters in this group was two times significantly higher than that in the control. So the intravenous injection of cMSCs has the restorative effect on the fertility at experimental pelvic inflammatory disease. |
| format | Article |
| id | doaj-art-5b1182598a844953b4049b3a3abb7f72 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5b1182598a844953b4049b3a3abb7f722025-02-03T00:59:21ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/20141322014132Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory DiseaseNataliia Volkova0Mariia Yukhta1Anatoliy Goltsev2Department of Cryopathophysiology and Immunology, Institute for Problems of Cryobiology and Сryomedicine of the National Academy of Sciences of Ukraine, Pereyaslavskaya Str. 23, Kharkov 61015, UkraineDepartment of Cryopathophysiology and Immunology, Institute for Problems of Cryobiology and Сryomedicine of the National Academy of Sciences of Ukraine, Pereyaslavskaya Str. 23, Kharkov 61015, UkraineDepartment of Cryopathophysiology and Immunology, Institute for Problems of Cryobiology and Сryomedicine of the National Academy of Sciences of Ukraine, Pereyaslavskaya Str. 23, Kharkov 61015, UkraineInflammatory disorders account for a significant percentage of gynecologic diseases, particularly in women of reproductive age. It is known that stem cells have anti-inflammatory and regenerative properties. Based on this, we investigated the effect of intravenous administration of cryopreserved mesenchymal stem cells (cMSCs) of bone marrow on experimental chronic inflammation of the ovaries. The paper shows that on the 21st day after cMSC therapy, leukocyte infiltration of ovaries was slightly relative to the control group without treatment, and the ratio of developing and atretic follicles in the animals with cMSC injection dramatically increased, while in the control, it still remained on the side of atretic forms. The number of apoptotic oocytes after stimulation of superovulation in the control group was significantly higher (85.3 ± 5.2%) than that in the animals with therapy (5.7 ± 0.8%). Relative number of fertilized eggs in the group with cMSC therapy was higher by 40% compare to that in the control. Pregnancy rate in natural estrous cycle after cell administration increased by 20%, and average number of litters in this group was two times significantly higher than that in the control. So the intravenous injection of cMSCs has the restorative effect on the fertility at experimental pelvic inflammatory disease.http://dx.doi.org/10.1155/2017/2014132 |
| spellingShingle | Nataliia Volkova Mariia Yukhta Anatoliy Goltsev Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease Stem Cells International |
| title | Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease |
| title_full | Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease |
| title_fullStr | Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease |
| title_full_unstemmed | Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease |
| title_short | Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease |
| title_sort | mesenchymal stem cells in restoration of fertility at experimental pelvic inflammatory disease |
| url | http://dx.doi.org/10.1155/2017/2014132 |
| work_keys_str_mv | AT nataliiavolkova mesenchymalstemcellsinrestorationoffertilityatexperimentalpelvicinflammatorydisease AT mariiayukhta mesenchymalstemcellsinrestorationoffertilityatexperimentalpelvicinflammatorydisease AT anatoliygoltsev mesenchymalstemcellsinrestorationoffertilityatexperimentalpelvicinflammatorydisease |