Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report
Mucinous carcinoma of the breast, also known as colloid carcinoma, is an uncommon type of differentiated adenocarcinoma, representing only 2% of all invasive breast carcinomas. It usually occurs in women ≥ 60 years of age. Mucinous carcinoma is characterized by clusters of epithelial tumour cells su...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324013931 |
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| author | Chiara Adriana Pistolese, MD, PhD Francesca Di Giuliano, MD, PhD Martina Cerocchi, MD Maria Volpe, MD Martina Cerasi Dellanea, MD Flavia Briganti, MD Paola Elda Gigliotti, MD Carolina Goffredo, MD Lucia Giudice, MD Diletta Caccia, MD Francesca Servadei, MD Adriano De Majo, MD, PhD Marco Materazzo, MD Giorgio Pistilli, MD Gianluca Vanni, MD, PhD Valeria Liberto, MD |
| author_facet | Chiara Adriana Pistolese, MD, PhD Francesca Di Giuliano, MD, PhD Martina Cerocchi, MD Maria Volpe, MD Martina Cerasi Dellanea, MD Flavia Briganti, MD Paola Elda Gigliotti, MD Carolina Goffredo, MD Lucia Giudice, MD Diletta Caccia, MD Francesca Servadei, MD Adriano De Majo, MD, PhD Marco Materazzo, MD Giorgio Pistilli, MD Gianluca Vanni, MD, PhD Valeria Liberto, MD |
| author_sort | Chiara Adriana Pistolese, MD, PhD |
| collection | DOAJ |
| description | Mucinous carcinoma of the breast, also known as colloid carcinoma, is an uncommon type of differentiated adenocarcinoma, representing only 2% of all invasive breast carcinomas. It usually occurs in women ≥ 60 years of age. Mucinous carcinoma is characterized by clusters of epithelial tumour cells suspended in pools of extracellular mucin and is further divided in 2 subgroups, pure and mixed. Compared to invasive ductal carcinoma, mucinous carcinoma has a better prognosis, being characterized by a lower incidence of nodal involvement and a more favorable histological grade, with low proliferative activity and high expression of hormone receptors. Overall 10-year survival is estimated to be more than 90%. We present a case of a 57-year-old female patient who presented a palpable mass in the right breast for at least 2 years. On examination the whole breast appeared swollen, congestive and painless to palpation. Breast ultrasound, breast MRI and tru-cut biopsy were performed and suggested an advanced infiltrated carcinoma with mucinous aspects. Immunohistochemistry study demonstrated ER positivity (95%), PR low (5%), HER-2-Neu negativity (score 0) and proliferative index (Ki67) of 20%, determining a Luminal B-like (HER 2-negative) subtype. The patient was then candidated to mastectomy surgery and breast reconstruction with DIEP flap. Axillary lymp-nodes were sampled surgically. |
| format | Article |
| id | doaj-art-5b0e133300fb44dcbcd326689923fb55 |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-5b0e133300fb44dcbcd326689923fb552025-01-18T05:04:11ZengElsevierRadiology Case Reports1930-04332025-03-0120317761783Radiological images of an advanced invasive carcinoma with mucinous aspects: A case reportChiara Adriana Pistolese, MD, PhD0Francesca Di Giuliano, MD, PhD1Martina Cerocchi, MD2Maria Volpe, MD3Martina Cerasi Dellanea, MD4Flavia Briganti, MD5Paola Elda Gigliotti, MD6Carolina Goffredo, MD7Lucia Giudice, MD8Diletta Caccia, MD9Francesca Servadei, MD10Adriano De Majo, MD, PhD11Marco Materazzo, MD12Giorgio Pistilli, MD13Gianluca Vanni, MD, PhD14Valeria Liberto, MD15Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, Rome, 00133, Italy; Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Viale Oxford 81, Rome, 00133, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, Italy; Corresponding author.Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyDepartment of Experimental Medicine, University of Rome “Tor Vergata”, Rome, ItalyDepartment of Surgical Science, Breast Unit, Policlinico Tor Vergata University, Rome, ItalyDepartment of Surgical Science, Breast Unit, Policlinico Tor Vergata University, Rome, Italy; Applied Medical-Surgical Sciences, Breast Oncoplastic Surgery, University of Rome Tor Vergata, Rome, ItalyDepartment of Surgical Science, Breast Unit, Policlinico Tor Vergata University, Rome, ItalyDepartment of Surgical Science, Breast Unit, Policlinico Tor Vergata University, Rome, Italy; Applied Medical-Surgical Sciences, Breast Oncoplastic Surgery, University of Rome Tor Vergata, Rome, ItalyDiagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, ItalyMucinous carcinoma of the breast, also known as colloid carcinoma, is an uncommon type of differentiated adenocarcinoma, representing only 2% of all invasive breast carcinomas. It usually occurs in women ≥ 60 years of age. Mucinous carcinoma is characterized by clusters of epithelial tumour cells suspended in pools of extracellular mucin and is further divided in 2 subgroups, pure and mixed. Compared to invasive ductal carcinoma, mucinous carcinoma has a better prognosis, being characterized by a lower incidence of nodal involvement and a more favorable histological grade, with low proliferative activity and high expression of hormone receptors. Overall 10-year survival is estimated to be more than 90%. We present a case of a 57-year-old female patient who presented a palpable mass in the right breast for at least 2 years. On examination the whole breast appeared swollen, congestive and painless to palpation. Breast ultrasound, breast MRI and tru-cut biopsy were performed and suggested an advanced infiltrated carcinoma with mucinous aspects. Immunohistochemistry study demonstrated ER positivity (95%), PR low (5%), HER-2-Neu negativity (score 0) and proliferative index (Ki67) of 20%, determining a Luminal B-like (HER 2-negative) subtype. The patient was then candidated to mastectomy surgery and breast reconstruction with DIEP flap. Axillary lymp-nodes were sampled surgically.http://www.sciencedirect.com/science/article/pii/S1930043324013931Breast cancerBreast MRIMucinous carcinomaSurgeryBIRADSBreast biopsy |
| spellingShingle | Chiara Adriana Pistolese, MD, PhD Francesca Di Giuliano, MD, PhD Martina Cerocchi, MD Maria Volpe, MD Martina Cerasi Dellanea, MD Flavia Briganti, MD Paola Elda Gigliotti, MD Carolina Goffredo, MD Lucia Giudice, MD Diletta Caccia, MD Francesca Servadei, MD Adriano De Majo, MD, PhD Marco Materazzo, MD Giorgio Pistilli, MD Gianluca Vanni, MD, PhD Valeria Liberto, MD Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report Radiology Case Reports Breast cancer Breast MRI Mucinous carcinoma Surgery BIRADS Breast biopsy |
| title | Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report |
| title_full | Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report |
| title_fullStr | Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report |
| title_full_unstemmed | Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report |
| title_short | Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report |
| title_sort | radiological images of an advanced invasive carcinoma with mucinous aspects a case report |
| topic | Breast cancer Breast MRI Mucinous carcinoma Surgery BIRADS Breast biopsy |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324013931 |
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