Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report

Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report

Mucinous carcinoma of the breast, also known as colloid carcinoma, is an uncommon type of differentiated adenocarcinoma, representing only 2% of all invasive breast carcinomas. It usually occurs in women ≥ 60 years of age. Mucinous carcinoma is characterized by clusters of epithelial tumour cells su...

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Main Authors: Chiara Adriana Pistolese, MD, PhD, Francesca Di Giuliano, MD, PhD, Martina Cerocchi, MD, Maria Volpe, MD, Martina Cerasi Dellanea, MD, Flavia Briganti, MD, Paola Elda Gigliotti, MD, Carolina Goffredo, MD, Lucia Giudice, MD, Diletta Caccia, MD, Francesca Servadei, MD, Adriano De Majo, MD, PhD, Marco Materazzo, MD, Giorgio Pistilli, MD, Gianluca Vanni, MD, PhD, Valeria Liberto, MD
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Radiology Case Reports
Subjects:
Breast cancer
Breast MRI
Mucinous carcinoma
Surgery
BIRADS
Breast biopsy
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043324013931
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Summary:Mucinous carcinoma of the breast, also known as colloid carcinoma, is an uncommon type of differentiated adenocarcinoma, representing only 2% of all invasive breast carcinomas. It usually occurs in women ≥ 60 years of age. Mucinous carcinoma is characterized by clusters of epithelial tumour cells suspended in pools of extracellular mucin and is further divided in 2 subgroups, pure and mixed. Compared to invasive ductal carcinoma, mucinous carcinoma has a better prognosis, being characterized by a lower incidence of nodal involvement and a more favorable histological grade, with low proliferative activity and high expression of hormone receptors. Overall 10-year survival is estimated to be more than 90%. We present a case of a 57-year-old female patient who presented a palpable mass in the right breast for at least 2 years. On examination the whole breast appeared swollen, congestive and painless to palpation. Breast ultrasound, breast MRI and tru-cut biopsy were performed and suggested an advanced infiltrated carcinoma with mucinous aspects. Immunohistochemistry study demonstrated ER positivity (95%), PR low (5%), HER-2-Neu negativity (score 0) and proliferative index (Ki67) of 20%, determining a Luminal B-like (HER 2-negative) subtype. The patient was then candidated to mastectomy surgery and breast reconstruction with DIEP flap. Axillary lymp-nodes were sampled surgically.
ISSN:1930-0433

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