Investigation of the efficacy of tyrosol on doxorubicin-induced acute cardiotoxicity in rats
<b>Aim:</b> In this study, it was aimed to investigate the efficacy of tyrosol on cardiotoxicity induced by doxorubicin.<p> <b>Materials and Methods:</b> Rats were divided into 4 groups and each group included 8 rats. Groups 1 and 2 were given 1 ml of physiological sali...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2022-09-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1399 |
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| Summary: | <b>Aim:</b> In this study, it was aimed to investigate the efficacy of tyrosol on
cardiotoxicity induced by doxorubicin.<p>
<b>Materials and Methods:</b> Rats were divided into 4 groups and each group
included 8 rats. Groups 1 and 2 were given 1 ml of physiological saline,
while groups 3 and 4 were given 20 mg/kg of tyrosol. In saline and tyrosol
administrations, the oral gavage method was used. In addition, a single dose
of 15 mg/kg dose of doxorubicin was administered intraperitoneally to group
2 and group 4 on the 12th day of the trial. On the 14th day of the experiment,
serum and tissue samples were taken from the anesthetized rats and then
euthanized. Serum creatine kinase MB and creatine kinase activities were
analyzed. Heart tissues were extracted, and histological and oxidative stress
characteristics were measured in these tissues. Heart tissue malondialdehyde
and reduced glutathione levels, catalase and glutathione peroxidase activities
were assessed spectrophotometrically.<p>
<b>Results: </b>Tyrosol pretreatment inhibited doxorubicin-induced increase
in heart tissue malondialdehyde level (p<0.05), the decrease in reduced
glutathione level and glutathione peroxidase enzyme activity, and suppressed
doxorubicin-induced oxidative stress in the heart tissue. In terms of cardiac
tissue catalase enzyme activity, no differences were found between the
groups. Because of the reduction in oxidative damage in the heart, the serum
creatine kinase MB and creatine kinase activity decreased dramatically
(p<0.05). Furthermore, it was discovered that tyrosol pretreatment reduced
the histopathological lesions caused by doxorubicin in cardiac tissue.<p>
<b>Conclusion:</b> It is thought that the administration of tyrosol may reduce the
cardiotoxicity caused by doxorubicin. |
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| ISSN: | 1309-6958 2146-1953 |