High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients
The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated t...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/9327136 |
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| author | Han Li Xiangxue Lu Ruifang Xiong Shixiang Wang |
| author_facet | Han Li Xiangxue Lu Ruifang Xiong Shixiang Wang |
| author_sort | Han Li |
| collection | DOAJ |
| description | The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months. The primary end point was all-cause mortality and cardiovascular mortality. Multivariable Cox regression was used to calculate the adjusted hazard ratios for NLR on all-cause and cardiovascular survival. We pinpointed that higher NLR in HD patients was a predictor of increased PP, LVMI, and IMT; HD patients with higher NLR had a lower survival at the end of the study; furthermore, high NLR was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. In conclusion, higher NLR in HD patients was associated with cardiovascular risk factors and mortality. |
| format | Article |
| id | doaj-art-5afea442e5b449d1a9edaa437440f9cc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5afea442e5b449d1a9edaa437440f9cc2025-02-03T06:13:27ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/93271369327136High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis PatientsHan Li0Xiangxue Lu1Ruifang Xiong2Shixiang Wang3Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaThe neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months. The primary end point was all-cause mortality and cardiovascular mortality. Multivariable Cox regression was used to calculate the adjusted hazard ratios for NLR on all-cause and cardiovascular survival. We pinpointed that higher NLR in HD patients was a predictor of increased PP, LVMI, and IMT; HD patients with higher NLR had a lower survival at the end of the study; furthermore, high NLR was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. In conclusion, higher NLR in HD patients was associated with cardiovascular risk factors and mortality.http://dx.doi.org/10.1155/2017/9327136 |
| spellingShingle | Han Li Xiangxue Lu Ruifang Xiong Shixiang Wang High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients Mediators of Inflammation |
| title | High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients |
| title_full | High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients |
| title_fullStr | High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients |
| title_full_unstemmed | High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients |
| title_short | High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients |
| title_sort | high neutrophil to lymphocyte ratio predicts cardiovascular mortality in chronic hemodialysis patients |
| url | http://dx.doi.org/10.1155/2017/9327136 |
| work_keys_str_mv | AT hanli highneutrophiltolymphocyteratiopredictscardiovascularmortalityinchronichemodialysispatients AT xiangxuelu highneutrophiltolymphocyteratiopredictscardiovascularmortalityinchronichemodialysispatients AT ruifangxiong highneutrophiltolymphocyteratiopredictscardiovascularmortalityinchronichemodialysispatients AT shixiangwang highneutrophiltolymphocyteratiopredictscardiovascularmortalityinchronichemodialysispatients |