In Vitro Systems for the Study of Hepatitis C Virus Infection
The study of a virus is made possible by the availability of culture systems in which the viral lifecycle can be realized. Such systems support robust virus entry, replication, assembly, and secretion of nascent virions. Furthermore, culture models provide a platform in which therapeutic interventio...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/292591 |
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| _version_ | 1832565102709047296 |
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| author | Garrick K. Wilson Zania Stamataki |
| author_facet | Garrick K. Wilson Zania Stamataki |
| author_sort | Garrick K. Wilson |
| collection | DOAJ |
| description | The study of a virus is made possible by the availability of culture systems in which the viral lifecycle can be realized. Such systems support robust virus entry, replication, assembly, and secretion of nascent virions. Furthermore, culture models provide a platform in which therapeutic interventions can be devised or monitored. Hepatitis C virus (HCV) has a restricted tropism to human and chimpanzees; thus investigations of HCV biology have been hindered for many years due to a lack of small animal models. Nevertheless, significant efforts have been directed at developing cell culture models to elucidate the viral lifecycle in vitro. HCV primarily infects liver parenchymal cells commonly known as hepatocytes. The liver is a highly specialized and complex organ and the development of in vitro systems that reflects this complexity has proven difficult. Consequently, host cell receptor molecules that potentiate HCV infection were identified over a decade after the virus was discovered. A summary of the various HCV in vitro culture models, their advantages, and disadvantages are described. |
| format | Article |
| id | doaj-art-5af7bd86b8454f34842d7d8510a1d7d4 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-5af7bd86b8454f34842d7d8510a1d7d42025-02-03T01:09:28ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/292591292591In Vitro Systems for the Study of Hepatitis C Virus InfectionGarrick K. Wilson0Zania Stamataki1NIHR Biomedical Research Unit and Centre for Liver Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UKNIHR Biomedical Research Unit and Centre for Liver Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UKThe study of a virus is made possible by the availability of culture systems in which the viral lifecycle can be realized. Such systems support robust virus entry, replication, assembly, and secretion of nascent virions. Furthermore, culture models provide a platform in which therapeutic interventions can be devised or monitored. Hepatitis C virus (HCV) has a restricted tropism to human and chimpanzees; thus investigations of HCV biology have been hindered for many years due to a lack of small animal models. Nevertheless, significant efforts have been directed at developing cell culture models to elucidate the viral lifecycle in vitro. HCV primarily infects liver parenchymal cells commonly known as hepatocytes. The liver is a highly specialized and complex organ and the development of in vitro systems that reflects this complexity has proven difficult. Consequently, host cell receptor molecules that potentiate HCV infection were identified over a decade after the virus was discovered. A summary of the various HCV in vitro culture models, their advantages, and disadvantages are described.http://dx.doi.org/10.1155/2012/292591 |
| spellingShingle | Garrick K. Wilson Zania Stamataki In Vitro Systems for the Study of Hepatitis C Virus Infection International Journal of Hepatology |
| title | In Vitro Systems for the Study of Hepatitis C Virus Infection |
| title_full | In Vitro Systems for the Study of Hepatitis C Virus Infection |
| title_fullStr | In Vitro Systems for the Study of Hepatitis C Virus Infection |
| title_full_unstemmed | In Vitro Systems for the Study of Hepatitis C Virus Infection |
| title_short | In Vitro Systems for the Study of Hepatitis C Virus Infection |
| title_sort | in vitro systems for the study of hepatitis c virus infection |
| url | http://dx.doi.org/10.1155/2012/292591 |
| work_keys_str_mv | AT garrickkwilson invitrosystemsforthestudyofhepatitiscvirusinfection AT zaniastamataki invitrosystemsforthestudyofhepatitiscvirusinfection |