Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3

Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3

Enzymatically oxygenated phospholipids (eoxPL) from lipoxygenases (LOX) or cyclooxygenase (COX) are prothrombotic. Their generation in arterial disease, and their modulation by cardiovascular therapies is unknown. Furthermore, the Lands cycle acyl-transferases that catalyze their formation are unide...

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Main Authors: Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Lipid Research
Subjects:
lipidomics
thrombosis
phospholipids
acute coronary syndrome
platelets
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524002323
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