Study on the invitro synergistic susceptibility and biofilm inhibition mechanism of ceftazidime-avibactam combined with aztreonam against carbapenem-resistant Klebsiella pneumoniae

Study on the invitro synergistic susceptibility and biofilm inhibition mechanism of ceftazidime-avibactam combined with aztreonam against carbapenem-resistant Klebsiella pneumoniae

ObjectiveThis study aims to investigate the synergistic effects and biofilm inhibition mechanisms of ceftazidime-avibactam (CZA) combined with aztreonam (ATM) against carbapenem-resistant Klebsiella pneumonia (CRKP) commonly found in the local clinical setting, providing new insights for clinical an...

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Bibliographic Details
Main Authors: Guangfen Wang, Hui Zhang, Qiaoping Wu, Jianqiang Xu, Xuedan Qiu, Jinyuan Chen, Fujie Cui, Jian Zhou, Qingcao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Microbiology
Subjects:
CRKP
carbapenemase
ceftazidime-avibactam
aztreonam
combined drug sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1542029/full
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