Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice

Bee pollen has potential in preventing metabolic syndrome (MetS). The present study aimed to investigate the effect of yeast-fermented wall-broken bee pollen (YB) intervention on ICR mice with MetS induced with a high-fat (HF) diet. After YB intervention in mice for 16 weeks, the effect on alleviati...

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Main Authors: Sha Yan, Kai Wang, Xiaoying Wang, Aiqun Ou, Feiran Wang, Liming Wu, Xiaofeng Xue
Format: Article
Language:English
Published: Tsinghua University Press 2021-05-01
Series:Food Science and Human Wellness
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213453021000355
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author Sha Yan
Kai Wang
Xiaoying Wang
Aiqun Ou
Feiran Wang
Liming Wu
Xiaofeng Xue
author_facet Sha Yan
Kai Wang
Xiaoying Wang
Aiqun Ou
Feiran Wang
Liming Wu
Xiaofeng Xue
author_sort Sha Yan
collection DOAJ
description Bee pollen has potential in preventing metabolic syndrome (MetS). The present study aimed to investigate the effect of yeast-fermented wall-broken bee pollen (YB) intervention on ICR mice with MetS induced with a high-fat (HF) diet. After YB intervention in mice for 16 weeks, the effect on alleviating MetS was evaluated based on MetS serum parameters, hepatic oxidant status markers and gut microbial populations. The results of animal experiment showed that YB intervention attenuated MetS. Based on multivariate statistical analysis results, YB treatment significantly increased glutathione S-transferase (GST) and catalase (CAT) activities and decreased the malondialdehyde (MDA) level in the liver. Further investigation showed that YB restored the Nrf-2-Keap-1 pathway to alleviate oxidative stress. Additionally, gut microbial community analysis revealed that YB restored the increase in the Firmicutes to Bacteroidetes (F/B) ratio (6.94 for the HF group and 3.74 for HF + YB group) and improved Lactobacillus and Lactococcus abundance induced by the HF diet. Overall, YB improved function and prevented MetS by modulating the gut microbiota and alleviating oxidative stress.
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series Food Science and Human Wellness
spelling doaj-art-5ad0f8a9837c4a919dac9efa46705cce2025-02-03T10:36:10ZengTsinghua University PressFood Science and Human Wellness2213-45302021-05-01103345355Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced miceSha Yan0Kai Wang1Xiaoying Wang2Aiqun Ou3Feiran Wang4Liming Wu5Xiaofeng Xue6Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China; College of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, ChinaInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, ChinaInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, ChinaInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, ChinaInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, ChinaInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China; Innovation Research Team of Risk Assessment for Bee Products Quality and Safety of the Ministry of Agriculture, Beijing 100093, China; Corresponding author. Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China; Corresponding author. Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.Bee pollen has potential in preventing metabolic syndrome (MetS). The present study aimed to investigate the effect of yeast-fermented wall-broken bee pollen (YB) intervention on ICR mice with MetS induced with a high-fat (HF) diet. After YB intervention in mice for 16 weeks, the effect on alleviating MetS was evaluated based on MetS serum parameters, hepatic oxidant status markers and gut microbial populations. The results of animal experiment showed that YB intervention attenuated MetS. Based on multivariate statistical analysis results, YB treatment significantly increased glutathione S-transferase (GST) and catalase (CAT) activities and decreased the malondialdehyde (MDA) level in the liver. Further investigation showed that YB restored the Nrf-2-Keap-1 pathway to alleviate oxidative stress. Additionally, gut microbial community analysis revealed that YB restored the increase in the Firmicutes to Bacteroidetes (F/B) ratio (6.94 for the HF group and 3.74 for HF + YB group) and improved Lactobacillus and Lactococcus abundance induced by the HF diet. Overall, YB improved function and prevented MetS by modulating the gut microbiota and alleviating oxidative stress.http://www.sciencedirect.com/science/article/pii/S2213453021000355Bee pollenfermentationGut microbial communityMetabolic syndrome
spellingShingle Sha Yan
Kai Wang
Xiaoying Wang
Aiqun Ou
Feiran Wang
Liming Wu
Xiaofeng Xue
Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice
Food Science and Human Wellness
Bee pollen
fermentation
Gut microbial community
Metabolic syndrome
title Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice
title_full Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice
title_fullStr Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice
title_full_unstemmed Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice
title_short Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice
title_sort effect of fermented bee pollen on metabolic syndrome in high fat diet induced mice
topic Bee pollen
fermentation
Gut microbial community
Metabolic syndrome
url http://www.sciencedirect.com/science/article/pii/S2213453021000355
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