Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina
Introduction: Knowledge of the etiology and antimicrobial susceptibility patterns of uropathogens is important for determining the best treatment option. This study aimed to determine the distribution and antibiotic susceptibility patterns of bacterial strains isolated from adult male outpatients....
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The Journal of Infection in Developing Countries
2014-06-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/3766 |
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| author | Hugo E Villar Mónica B Jugo Alejandro Macan Matias Visser Mariana Hidalgo Gustavo Cesar Maccallini |
| author_facet | Hugo E Villar Mónica B Jugo Alejandro Macan Matias Visser Mariana Hidalgo Gustavo Cesar Maccallini |
| author_sort | Hugo E Villar |
| collection | DOAJ |
| description | Introduction: Knowledge of the etiology and antimicrobial susceptibility patterns of uropathogens is important for determining the best treatment option. This study aimed to determine the distribution and antibiotic susceptibility patterns of bacterial strains isolated from adult male outpatients.
Methodology: Between November 2012 and April 2013, 3,105 community urine samples were analyzed from adult male patients who attended the Laboratorio Hidalgo, Buenos Aires, Argentina. Antimicrobial susceptibility testing was performed by the Kirby-Bauer disc diffusion method. Isolates resistant to third generation cephalosporin were tested for extended-spectrum beta-lactamase (ESBL) production using the double-disk synergy test.
Results: Of the 3,105 urine samples analyzed, 791 (25.5%) had significant bacteriuria. The frequency of positive urine cultures increased significantly with patient age. Escherichia coli was isolated most frequently (47.3%), followed by Enterococcus faecalis (13.6%), and Klebsiella pneumoniae (11.9%). Gram-negative organisms represented 78.8% of urinary pathogens. The highest activities against Gram-negative bacteria were found with imipenem (99.0%), amikacin (98.1%), ertapenem (94.2%), fosfomycin (90.7%), and piperacillin-tazobactam (90.1%). The frequencies of ESBLs among E. coli, K. pneumoniae, and P. mirabilis were 15.2 %, 22.3%, and 8%, respectively. Fosfomycin, piperacillin-tazobactam, and nitrofurantoin were most effective against Gram-positive organisms.
Conclusions: Fosfomycin may be an excellent option for cystitis treatment in patients without risk factors, whereas piperacillin-tazobactam is preferred for the treatment of parenchymatous UTIs, complicated UTIs, and UTIs associated with risk factors. To ensure the optimal selection of antibiotics, physicians should have access to up-to-date information about the local prevalence of antimicrobial resistance.
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| format | Article |
| id | doaj-art-5acba6f5d2fc46b98b9d41b841c23f3d |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-5acba6f5d2fc46b98b9d41b841c23f3d2025-08-20T02:16:14ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802014-06-0180610.3855/jidc.3766Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in ArgentinaHugo E Villar0Mónica B Jugo1Alejandro Macan2Matias Visser3Mariana Hidalgo4Gustavo Cesar Maccallini5Laboratorio Hidalgo, Buenos Aires, ArgentinaLaboratorio Hidalgo, Buenos Aires, ArgentinaMartinez Medical Center, Buenos Aires, ArgentinaLaboratorio Hidalgo, Buenos Aires, ArgentinaLaboratorio Hidalgo, Buenos Aires, ArgentinaLaboratorio Hidalgo, Buenos Aires, ArgentinaIntroduction: Knowledge of the etiology and antimicrobial susceptibility patterns of uropathogens is important for determining the best treatment option. This study aimed to determine the distribution and antibiotic susceptibility patterns of bacterial strains isolated from adult male outpatients. Methodology: Between November 2012 and April 2013, 3,105 community urine samples were analyzed from adult male patients who attended the Laboratorio Hidalgo, Buenos Aires, Argentina. Antimicrobial susceptibility testing was performed by the Kirby-Bauer disc diffusion method. Isolates resistant to third generation cephalosporin were tested for extended-spectrum beta-lactamase (ESBL) production using the double-disk synergy test. Results: Of the 3,105 urine samples analyzed, 791 (25.5%) had significant bacteriuria. The frequency of positive urine cultures increased significantly with patient age. Escherichia coli was isolated most frequently (47.3%), followed by Enterococcus faecalis (13.6%), and Klebsiella pneumoniae (11.9%). Gram-negative organisms represented 78.8% of urinary pathogens. The highest activities against Gram-negative bacteria were found with imipenem (99.0%), amikacin (98.1%), ertapenem (94.2%), fosfomycin (90.7%), and piperacillin-tazobactam (90.1%). The frequencies of ESBLs among E. coli, K. pneumoniae, and P. mirabilis were 15.2 %, 22.3%, and 8%, respectively. Fosfomycin, piperacillin-tazobactam, and nitrofurantoin were most effective against Gram-positive organisms. Conclusions: Fosfomycin may be an excellent option for cystitis treatment in patients without risk factors, whereas piperacillin-tazobactam is preferred for the treatment of parenchymatous UTIs, complicated UTIs, and UTIs associated with risk factors. To ensure the optimal selection of antibiotics, physicians should have access to up-to-date information about the local prevalence of antimicrobial resistance. https://jidc.org/index.php/journal/article/view/3766antimicrobial susceptibilitycommunity-acquired urinary tractempirical treatmentinfectionuropathogen |
| spellingShingle | Hugo E Villar Mónica B Jugo Alejandro Macan Matias Visser Mariana Hidalgo Gustavo Cesar Maccallini Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina Journal of Infection in Developing Countries antimicrobial susceptibility community-acquired urinary tract empirical treatment infection uropathogen |
| title | Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina |
| title_full | Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina |
| title_fullStr | Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina |
| title_full_unstemmed | Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina |
| title_short | Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina |
| title_sort | frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in argentina |
| topic | antimicrobial susceptibility community-acquired urinary tract empirical treatment infection uropathogen |
| url | https://jidc.org/index.php/journal/article/view/3766 |
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