Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives
Necrotizing Enterocolitis (NEC) is a severe, life-threatening inflammatory condition of the gastrointestinal tract, especially affecting preterm infants. This review consolidates evidence from various biomedical disciplines to elucidate the complex pathogenesis of NEC, integrating insights from clin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2451071 |
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| author | Deshuang Zhang Dongke Xie Yi Qu Dezhi Mu Shaopu Wang |
| author_facet | Deshuang Zhang Dongke Xie Yi Qu Dezhi Mu Shaopu Wang |
| author_sort | Deshuang Zhang |
| collection | DOAJ |
| description | Necrotizing Enterocolitis (NEC) is a severe, life-threatening inflammatory condition of the gastrointestinal tract, especially affecting preterm infants. This review consolidates evidence from various biomedical disciplines to elucidate the complex pathogenesis of NEC, integrating insights from clinical, microbial, and molecular perspectives. It emphasizes the modulation of NEC-associated inflammatory pathways by probiotics and novel biologics, highlighting their therapeutic potential. We further critically examine dysbiotic alterations within the gut microbiota, with a particular focus on imbalances in bacterial and viral communities, which may contribute to the onset of NEC. The intricate interactions among toll-like receptor 4 (TLR4), microvascular integrity, immune activation, and the inflammatory milieu are meticulously summarized, offering a sophisticated understanding of NEC pathophysiology. This academic review aims to enhance the etiological comprehension of NEC, promote the development of targeted therapeutic interventions, and impart the significant impact of perinatal factors on the formulation of preventive and curative strategies for the disease. |
| format | Article |
| id | doaj-art-5ac3d697c355420d881db615464a9900 |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-5ac3d697c355420d881db615464a99002025-01-23T04:27:02ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2451071Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectivesDeshuang Zhang0Dongke Xie1Yi Qu2Dezhi Mu3Shaopu Wang4Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, ChinaDivision of Neonatology/Pediatric Surgery, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, ChinaNecrotizing Enterocolitis (NEC) is a severe, life-threatening inflammatory condition of the gastrointestinal tract, especially affecting preterm infants. This review consolidates evidence from various biomedical disciplines to elucidate the complex pathogenesis of NEC, integrating insights from clinical, microbial, and molecular perspectives. It emphasizes the modulation of NEC-associated inflammatory pathways by probiotics and novel biologics, highlighting their therapeutic potential. We further critically examine dysbiotic alterations within the gut microbiota, with a particular focus on imbalances in bacterial and viral communities, which may contribute to the onset of NEC. The intricate interactions among toll-like receptor 4 (TLR4), microvascular integrity, immune activation, and the inflammatory milieu are meticulously summarized, offering a sophisticated understanding of NEC pathophysiology. This academic review aims to enhance the etiological comprehension of NEC, promote the development of targeted therapeutic interventions, and impart the significant impact of perinatal factors on the formulation of preventive and curative strategies for the disease.https://www.tandfonline.com/doi/10.1080/19490976.2025.2451071Necrotizing enterocolitis (NEC)preterm infantsmicrobesdysbiosistoll-like receptor 4 (TLR4)mechanism |
| spellingShingle | Deshuang Zhang Dongke Xie Yi Qu Dezhi Mu Shaopu Wang Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives Gut Microbes Necrotizing enterocolitis (NEC) preterm infants microbes dysbiosis toll-like receptor 4 (TLR4) mechanism |
| title | Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives |
| title_full | Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives |
| title_fullStr | Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives |
| title_full_unstemmed | Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives |
| title_short | Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives |
| title_sort | digging deeper into necrotizing enterocolitis bridging clinical microbial and molecular perspectives |
| topic | Necrotizing enterocolitis (NEC) preterm infants microbes dysbiosis toll-like receptor 4 (TLR4) mechanism |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2451071 |
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