β3-Adrenergic receptor antagonism improves cardiac and vascular functions but did not modulate survival in a murine resuscitated septic shock model

β3-Adrenergic receptor antagonism improves cardiac and vascular functions but did not modulate survival in a murine resuscitated septic shock model

Abstract Background Recent findings suggest that β3-adrenergic receptors (β3-AR) could play a role in the hemodynamic regulation, but their function in septic shock remains unclear. This study investigates the modulation of β3-AR in an experimental murine model of resuscitated septic shock on in viv...

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Bibliographic Details
Main Authors: Eugénie Hagimont, Marc-Damien Lourenco-Rodrigues, Benjamin-Glenn Chousterman, Frances Yen-Potin, Manon Durand, Antoine Kimmoun
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:Intensive Care Medicine Experimental
Subjects:
Septic shock
Receptor
Beta-3
Adrenergic
Vascular reactivity
Online Access:https://doi.org/10.1186/s40635-024-00705-9
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