Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure
Heart failure (HF) has emerged as a significant global public health challenge owing to its high rates of morbidity and mortality. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is regarded as a pivotal factor in the onset and progression of HF. Therefore, inhibiting the activati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1520482/full |
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| author | Ruifang Lin Ruifang Lin Yunfeng Yu Lixin Du Zehui Ding Zehui Ding Ziyan Wang Ziyan Wang Jiaming Wei Jiaming Wei Zhihua Guo Zhihua Guo |
| author_facet | Ruifang Lin Ruifang Lin Yunfeng Yu Lixin Du Zehui Ding Zehui Ding Ziyan Wang Ziyan Wang Jiaming Wei Jiaming Wei Zhihua Guo Zhihua Guo |
| author_sort | Ruifang Lin |
| collection | DOAJ |
| description | Heart failure (HF) has emerged as a significant global public health challenge owing to its high rates of morbidity and mortality. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is regarded as a pivotal factor in the onset and progression of HF. Therefore, inhibiting the activation of the NLRP3 inflammasome may represent a promising therapeutic approach for preventing and treating HF. The active ingredients serve as the foundation for the therapeutic effects of traditional Chinese medicine (TCM). Recent research has revealed significant advantages of TCM active ingredients in inhibiting the activation of the NLRP3 inflammasome and enhancing cardiac structure and function in HF. The study aimed to explore the impact of NLRP3 inflammasome activation on the onset and progression of HF, and to review the current advancements in utilizing TCM active ingredients to inhibit the NLRP3 inflammasome for preventing and treating HF. This provides a novel perspective for the future development of precise intervention strategies targeting the NLRP3 inflammasome to prevent and treat HF. |
| format | Article |
| id | doaj-art-5ab8b3c63bf74282a2c21d0309107b60 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-5ab8b3c63bf74282a2c21d0309107b602025-01-24T07:13:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15204821520482Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failureRuifang Lin0Ruifang Lin1Yunfeng Yu2Lixin Du3Zehui Ding4Zehui Ding5Ziyan Wang6Ziyan Wang7Jiaming Wei8Jiaming Wei9Zhihua Guo10Zhihua Guo11College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases, Hunan University of Chinese Medicine, Changsha, ChinaFirst Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases, Hunan University of Chinese Medicine, Changsha, ChinaFirst Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases, Hunan University of Chinese Medicine, Changsha, ChinaFirst Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaCollege of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases, Hunan University of Chinese Medicine, Changsha, ChinaHunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases, Hunan University of Chinese Medicine, Changsha, ChinaFirst Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHeart failure (HF) has emerged as a significant global public health challenge owing to its high rates of morbidity and mortality. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is regarded as a pivotal factor in the onset and progression of HF. Therefore, inhibiting the activation of the NLRP3 inflammasome may represent a promising therapeutic approach for preventing and treating HF. The active ingredients serve as the foundation for the therapeutic effects of traditional Chinese medicine (TCM). Recent research has revealed significant advantages of TCM active ingredients in inhibiting the activation of the NLRP3 inflammasome and enhancing cardiac structure and function in HF. The study aimed to explore the impact of NLRP3 inflammasome activation on the onset and progression of HF, and to review the current advancements in utilizing TCM active ingredients to inhibit the NLRP3 inflammasome for preventing and treating HF. This provides a novel perspective for the future development of precise intervention strategies targeting the NLRP3 inflammasome to prevent and treat HF.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1520482/fullNLRP3inflammasomeheart failureactive ingredienttraditional Chinese medicine |
| spellingShingle | Ruifang Lin Ruifang Lin Yunfeng Yu Lixin Du Zehui Ding Zehui Ding Ziyan Wang Ziyan Wang Jiaming Wei Jiaming Wei Zhihua Guo Zhihua Guo Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure Frontiers in Immunology NLRP3 inflammasome heart failure active ingredient traditional Chinese medicine |
| title | Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure |
| title_full | Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure |
| title_fullStr | Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure |
| title_full_unstemmed | Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure |
| title_short | Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure |
| title_sort | active ingredients of traditional chinese medicine inhibit nod like receptor protein 3 inflammasome a novel strategy for preventing and treating heart failure |
| topic | NLRP3 inflammasome heart failure active ingredient traditional Chinese medicine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1520482/full |
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