Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population
ABSTRACT Elevated blood pressure has previously been associated with increased levels of circulating extracellular vesicles (EVs). However, studies on the relevance of EV cargos to hypertension are limited. Secreted protein acidic and rich in cysteine (SPARC) is involved in many metabolic diseases a...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14954 |
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| author | Xueying Chen Han Guo Xinwei Li Yang Liu Xinxin Li Zhengshuo Cui Huijuan Ma Jianxun He Zhechun Zeng Huina Zhang |
| author_facet | Xueying Chen Han Guo Xinwei Li Yang Liu Xinxin Li Zhengshuo Cui Huijuan Ma Jianxun He Zhechun Zeng Huina Zhang |
| author_sort | Xueying Chen |
| collection | DOAJ |
| description | ABSTRACT Elevated blood pressure has previously been associated with increased levels of circulating extracellular vesicles (EVs). However, studies on the relevance of EV cargos to hypertension are limited. Secreted protein acidic and rich in cysteine (SPARC) is involved in many metabolic diseases and endothelial dysfunction pathological processes. This study aimed to explore the association of serum EV‐derived SPARC with hypertension incidence. We conducted a cross‐sectional study on 125 Chinese, including 76 hypertension patients and 49 normotensive patients. Serum EVs were prepared via ultracentrifugation. The concentrations of serum EV‐derived SPARC and serum SPARC were measured by Luminex Assay. The correlations between serum EV‐derived SPARC and clinical variables were analyzed. Multivariate logistic regression analysis determined the association of serum EV‐derived SPARC levels with hypertension. Interaction subgroup analysis was used to evaluate the interaction of the relevant baselines on the association between serum EV‐derived SPARC levels and hypertension. Our findings revealed that the levels of SPARC derived from serum EVs were markedly elevated in individuals with hypertension, averaging 20.60 ng/mL (p < 0.01), when contrasted with the levels observed in normotensive subjects, which were 14.25 ng/mL (p < 0.01) in average. Multivariate logistic regression analysis revealed that serum EV‐derived SPARC levels were positively associated with hypertension (odds ratio [OR] 1.095; 95% confidence interval [CI] = 1.031–1.163; p value, 0.003), after adjusting for confounding factors. Interaction subgroup analysis demonstrated that no significant interaction with hypertension was observed for any particular covariate. The present study reveals that the elevated levels of serum EV‐derived SPARC were independently associated with hypertension. |
| format | Article |
| id | doaj-art-5aaba668deba4ad2ac0df7c855b03427 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-5aaba668deba4ad2ac0df7c855b034272025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14954Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly PopulationXueying Chen0Han Guo1Xinwei Li2Yang Liu3Xinxin Li4Zhengshuo Cui5Huijuan Ma6Jianxun He7Zhechun Zeng8Huina Zhang9Beijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaBeijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaBeijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaBeijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaBeijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaBeijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaDepartment of Hypertension Beijing An Zhen Hospital Capital Medical University Beijing ChinaBeijing Anzhen Hospital Laboratory Department Beijing Anzhen Hospital Capital Medical University Beijing ChinaBeijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaBeijing An Zhen Hospital Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing ChinaABSTRACT Elevated blood pressure has previously been associated with increased levels of circulating extracellular vesicles (EVs). However, studies on the relevance of EV cargos to hypertension are limited. Secreted protein acidic and rich in cysteine (SPARC) is involved in many metabolic diseases and endothelial dysfunction pathological processes. This study aimed to explore the association of serum EV‐derived SPARC with hypertension incidence. We conducted a cross‐sectional study on 125 Chinese, including 76 hypertension patients and 49 normotensive patients. Serum EVs were prepared via ultracentrifugation. The concentrations of serum EV‐derived SPARC and serum SPARC were measured by Luminex Assay. The correlations between serum EV‐derived SPARC and clinical variables were analyzed. Multivariate logistic regression analysis determined the association of serum EV‐derived SPARC levels with hypertension. Interaction subgroup analysis was used to evaluate the interaction of the relevant baselines on the association between serum EV‐derived SPARC levels and hypertension. Our findings revealed that the levels of SPARC derived from serum EVs were markedly elevated in individuals with hypertension, averaging 20.60 ng/mL (p < 0.01), when contrasted with the levels observed in normotensive subjects, which were 14.25 ng/mL (p < 0.01) in average. Multivariate logistic regression analysis revealed that serum EV‐derived SPARC levels were positively associated with hypertension (odds ratio [OR] 1.095; 95% confidence interval [CI] = 1.031–1.163; p value, 0.003), after adjusting for confounding factors. Interaction subgroup analysis demonstrated that no significant interaction with hypertension was observed for any particular covariate. The present study reveals that the elevated levels of serum EV‐derived SPARC were independently associated with hypertension.https://doi.org/10.1111/jch.14954cross‐sectional studyextracellular vesiclehypertensionSPARC |
| spellingShingle | Xueying Chen Han Guo Xinwei Li Yang Liu Xinxin Li Zhengshuo Cui Huijuan Ma Jianxun He Zhechun Zeng Huina Zhang Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population The Journal of Clinical Hypertension cross‐sectional study extracellular vesicle hypertension SPARC |
| title | Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population |
| title_full | Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population |
| title_fullStr | Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population |
| title_full_unstemmed | Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population |
| title_short | Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population |
| title_sort | elevated serum extracellular vesicle packaged sparc in hypertension a cross sectional study in a middle aged and elderly population |
| topic | cross‐sectional study extracellular vesicle hypertension SPARC |
| url | https://doi.org/10.1111/jch.14954 |
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