Epigenetic Markers of Renal Function in African Americans
Chronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans. Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD. To better understand how these methylation mark...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Nursing Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/687519 |
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| _version_ | 1832554704748412928 |
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| author | Samantha M. Bomotti Jennifer A. Smith Alicia L. Zagel Jacquelyn Y. Taylor Stephen T. Turner Sharon L. R. Kardia |
| author_facet | Samantha M. Bomotti Jennifer A. Smith Alicia L. Zagel Jacquelyn Y. Taylor Stephen T. Turner Sharon L. R. Kardia |
| author_sort | Samantha M. Bomotti |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans. Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD. To better understand how these methylation markers play a role in kidney function, we measured 26,428 DNA methylation sites in 972 African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. We then evaluated (1) whether epigenetic markers are associated with estimated glomerular filtration rate (eGFR), (2) whether the significantly associated markers are also associated with traditional risk factors and/or novel biomarkers for eGFR, and (3) how much additional variation in eGFR is explained by epigenetic markers beyond established risk factors and biomarkers. The majority of methylation markers most significantly associated with eGFR (24 out of the top 30) appeared to function, at least in part, through pathways related to aging, inflammation, or cholesterol. However, six epigenetic markers were still able to significantly predict eGFR after adjustment for other risk factors. This work shows that epigenetic markers may offer valuable new insight into the complex pathophysiology of CKD in African Americans. |
| format | Article |
| id | doaj-art-5aa763029bc441739c59a5fd57cb78f2 |
| institution | Kabale University |
| issn | 2090-1429 2090-1437 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Nursing Research and Practice |
| spelling | doaj-art-5aa763029bc441739c59a5fd57cb78f22025-02-03T05:50:42ZengWileyNursing Research and Practice2090-14292090-14372013-01-01201310.1155/2013/687519687519Epigenetic Markers of Renal Function in African AmericansSamantha M. Bomotti0Jennifer A. Smith1Alicia L. Zagel2Jacquelyn Y. Taylor3Stephen T. Turner4Sharon L. R. Kardia5Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USADepartment of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, No. 4629, Ann Arbor, MI 48109, USACenter for Health Statistics, Washington State Department of Health, Olympia, WA 98501, USASchool of Nursing, Yale University, New Haven, CT 06477, USADivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USADepartment of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, No. 4629, Ann Arbor, MI 48109, USAChronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans. Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD. To better understand how these methylation markers play a role in kidney function, we measured 26,428 DNA methylation sites in 972 African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. We then evaluated (1) whether epigenetic markers are associated with estimated glomerular filtration rate (eGFR), (2) whether the significantly associated markers are also associated with traditional risk factors and/or novel biomarkers for eGFR, and (3) how much additional variation in eGFR is explained by epigenetic markers beyond established risk factors and biomarkers. The majority of methylation markers most significantly associated with eGFR (24 out of the top 30) appeared to function, at least in part, through pathways related to aging, inflammation, or cholesterol. However, six epigenetic markers were still able to significantly predict eGFR after adjustment for other risk factors. This work shows that epigenetic markers may offer valuable new insight into the complex pathophysiology of CKD in African Americans.http://dx.doi.org/10.1155/2013/687519 |
| spellingShingle | Samantha M. Bomotti Jennifer A. Smith Alicia L. Zagel Jacquelyn Y. Taylor Stephen T. Turner Sharon L. R. Kardia Epigenetic Markers of Renal Function in African Americans Nursing Research and Practice |
| title | Epigenetic Markers of Renal Function in African Americans |
| title_full | Epigenetic Markers of Renal Function in African Americans |
| title_fullStr | Epigenetic Markers of Renal Function in African Americans |
| title_full_unstemmed | Epigenetic Markers of Renal Function in African Americans |
| title_short | Epigenetic Markers of Renal Function in African Americans |
| title_sort | epigenetic markers of renal function in african americans |
| url | http://dx.doi.org/10.1155/2013/687519 |
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