NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients
Background. We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW). Methods. A cross-sectional study was performed in Afro-Caribbean dialysis patients...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2017/1312547 |
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| _version_ | 1832549231617900544 |
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| author | Jacques Ducros Laurent Larifla Henri Merault Lydia Foucan |
| author_facet | Jacques Ducros Laurent Larifla Henri Merault Lydia Foucan |
| author_sort | Jacques Ducros |
| collection | DOAJ |
| description | Background. We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW). Methods. A cross-sectional study was performed in Afro-Caribbean dialysis patients. One component in each of the 4 categories for the wasting syndrome was retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m2, serum creatinine ≤ 818 µmol/L, and normalized protein catabolic rate (nPCR) ≤ 0.8 g/kg/day. NT-proBNP was assessed using a chemiluminescence immunoassay. Two multivariate logistic regression models were performed to determine the parameters associated with high NT-proBNP concentrations. Results. In 207 HD patients, 16.9% had PEW (at least three components). LVEF lower than 60% was found in 13.8% of patients. NT-proBNP levels ranged from 125 to 33144 pg/mL. In model 1, high levels of NT-proBNP (≥6243 pg/mL) were independently associated with PEW OR 14.2 (3.25–62.4), male gender 2.80 (1.22–6.57), hsCRP > 5 mg/L 3.90 (1.77–8.57), and dialysis vintage > 3 years 3.84 (1.35–10.8). In model 2, LVEF OR was 0.93 (0.88–0.98). NT-proBNP concentrations were significantly higher when the PEW component number was higher. Conclusion. In dialysis patients, high NT-proBNP levels must draw attention to cardiac function but also to nutritional status. |
| format | Article |
| id | doaj-art-5aa5ddd03c8b4945b7254916930f899e |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-5aa5ddd03c8b4945b7254916930f899e2025-02-03T06:11:45ZengWileyInternational Journal of Nephrology2090-214X2090-21582017-01-01201710.1155/2017/13125471312547NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis PatientsJacques Ducros0Laurent Larifla1Henri Merault2Lydia Foucan3Centre de Dialyse AUDRA, Hôpital RICOU, Pointe-à-Pitre, Guadeloupe, FranceService de Cardiologie, Centre Hospitalier Universitaire, Guadeloupe, FranceCentre de Dialyse AUDRA, Hôpital RICOU, Pointe-à-Pitre, Guadeloupe, FranceCentre de Dialyse AUDRA, Hôpital RICOU, Pointe-à-Pitre, Guadeloupe, FranceBackground. We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW). Methods. A cross-sectional study was performed in Afro-Caribbean dialysis patients. One component in each of the 4 categories for the wasting syndrome was retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m2, serum creatinine ≤ 818 µmol/L, and normalized protein catabolic rate (nPCR) ≤ 0.8 g/kg/day. NT-proBNP was assessed using a chemiluminescence immunoassay. Two multivariate logistic regression models were performed to determine the parameters associated with high NT-proBNP concentrations. Results. In 207 HD patients, 16.9% had PEW (at least three components). LVEF lower than 60% was found in 13.8% of patients. NT-proBNP levels ranged from 125 to 33144 pg/mL. In model 1, high levels of NT-proBNP (≥6243 pg/mL) were independently associated with PEW OR 14.2 (3.25–62.4), male gender 2.80 (1.22–6.57), hsCRP > 5 mg/L 3.90 (1.77–8.57), and dialysis vintage > 3 years 3.84 (1.35–10.8). In model 2, LVEF OR was 0.93 (0.88–0.98). NT-proBNP concentrations were significantly higher when the PEW component number was higher. Conclusion. In dialysis patients, high NT-proBNP levels must draw attention to cardiac function but also to nutritional status.http://dx.doi.org/10.1155/2017/1312547 |
| spellingShingle | Jacques Ducros Laurent Larifla Henri Merault Lydia Foucan NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients International Journal of Nephrology |
| title | NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients |
| title_full | NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients |
| title_fullStr | NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients |
| title_full_unstemmed | NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients |
| title_short | NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients |
| title_sort | nt probnp cardiometabolic risk factors and nutritional status in hemodialysis patients |
| url | http://dx.doi.org/10.1155/2017/1312547 |
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