Breast Cancer Profile among Patients with a History of Chemoprevention
Purpose. This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease. Methods. Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided i...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2016/9216375 |
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| author | Freya R. Schnabel Sarah Pivo Jennifer Chun Shira Schwartz Ana Paula Refinetti Deborah Axelrod Amber Guth |
| author_facet | Freya R. Schnabel Sarah Pivo Jennifer Chun Shira Schwartz Ana Paula Refinetti Deborah Axelrod Amber Guth |
| author_sort | Freya R. Schnabel |
| collection | DOAJ |
| description | Purpose. This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease. Methods. Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided into primary (no history of breast cancer) and secondary (previous history of breast cancer) groups and compared to patients who never took chemoprevention. Results. 135 (6%) of 2430 women used chemoprevention. In the primary chemoprevention group (n = 18, 1%), 39% had completed >5 years of treatment, and fully 50% were on treatment at time of diagnosis. These patients were overwhelmingly diagnosed with ER/PR positive cancers (88%/65%) and were diagnosed with equal percentages (44%) of IDC and DCIS. 117 (87%) used secondary chemoprevention. Patients in this group were diagnosed with earlier stage disease and had lower rates of ER/PR-positivity (73%/65%) than the nonchemoprevention group (84%/72%). In the secondary group, 24% were on chemoprevention at time of diagnosis; 73% had completed >5 years of treatment. Conclusions. The majority of patients who used primary chemoprevention had not completed treatment prior to diagnosis, suggesting that the timing of initiation and compliance to prevention strategies are important in defining the pattern of disease in these patients. |
| format | Article |
| id | doaj-art-5a97c05b4fa14191a0957fa058a79260 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-5a97c05b4fa14191a0957fa058a792602025-02-03T06:06:06ZengWileyInternational Journal of Breast Cancer2090-31702090-31892016-01-01201610.1155/2016/92163759216375Breast Cancer Profile among Patients with a History of ChemopreventionFreya R. Schnabel0Sarah Pivo1Jennifer Chun2Shira Schwartz3Ana Paula Refinetti4Deborah Axelrod5Amber Guth6Department of Surgery, New York University Langone Medical Center, New York, NY, USASchool of Medicine, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USAPurpose. This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease. Methods. Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided into primary (no history of breast cancer) and secondary (previous history of breast cancer) groups and compared to patients who never took chemoprevention. Results. 135 (6%) of 2430 women used chemoprevention. In the primary chemoprevention group (n = 18, 1%), 39% had completed >5 years of treatment, and fully 50% were on treatment at time of diagnosis. These patients were overwhelmingly diagnosed with ER/PR positive cancers (88%/65%) and were diagnosed with equal percentages (44%) of IDC and DCIS. 117 (87%) used secondary chemoprevention. Patients in this group were diagnosed with earlier stage disease and had lower rates of ER/PR-positivity (73%/65%) than the nonchemoprevention group (84%/72%). In the secondary group, 24% were on chemoprevention at time of diagnosis; 73% had completed >5 years of treatment. Conclusions. The majority of patients who used primary chemoprevention had not completed treatment prior to diagnosis, suggesting that the timing of initiation and compliance to prevention strategies are important in defining the pattern of disease in these patients.http://dx.doi.org/10.1155/2016/9216375 |
| spellingShingle | Freya R. Schnabel Sarah Pivo Jennifer Chun Shira Schwartz Ana Paula Refinetti Deborah Axelrod Amber Guth Breast Cancer Profile among Patients with a History of Chemoprevention International Journal of Breast Cancer |
| title | Breast Cancer Profile among Patients with a History of Chemoprevention |
| title_full | Breast Cancer Profile among Patients with a History of Chemoprevention |
| title_fullStr | Breast Cancer Profile among Patients with a History of Chemoprevention |
| title_full_unstemmed | Breast Cancer Profile among Patients with a History of Chemoprevention |
| title_short | Breast Cancer Profile among Patients with a History of Chemoprevention |
| title_sort | breast cancer profile among patients with a history of chemoprevention |
| url | http://dx.doi.org/10.1155/2016/9216375 |
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