Effect of Noradrenaline on the Virulence Properties of Campylobacter Species
Campylobacter species cause a spectrum of illnesses in humans. The type of illness and the outcome is dependent on the virulence of the infecting pathogen strain and host immune status. Acute stress can seriously compromise host immunity and increase susceptibility to infection. Noradrenaline (NA) i...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2014/279075 |
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| author | Sree V. Aroori Tristan A. Cogan Tom J. Humphrey |
| author_facet | Sree V. Aroori Tristan A. Cogan Tom J. Humphrey |
| author_sort | Sree V. Aroori |
| collection | DOAJ |
| description | Campylobacter species cause a spectrum of illnesses in humans. The type of illness and the outcome is dependent on the virulence of the infecting pathogen strain and host immune status. Acute stress can seriously compromise host immunity and increase susceptibility to infection. Noradrenaline (NA) is a stress hormone. Several studies have shown that it stimulated growth and increased the pathogenicity of organisms including E. coli and Campylobacter jejuni. However, the effect of NA on other Campylobacter species is unknown. We have examined the effect of NA on growth rate, motility, invasion of T84 epithelial cells, and colonisation of chickens by diverse Campylobacter species. Campylobacter cultures grown with NA had reduced lag phases, increased growth rates, and higher final optical densities than controls. The motility of Campylobacter was also significantly increased in the presence of noradrenaline. Some of the Campylobacter strains tested also showed increased invasion of T84 epithelial cells, greater breakdown of tight junctions, and an enhanced potential to colonise chickens. Our results show that noradrenaline-induced enhancement of virulence of Campylobacter can influence the outcome of infection. |
| format | Article |
| id | doaj-art-5a93d3547a8a4402b6f2c857f27648ef |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-5a93d3547a8a4402b6f2c857f27648ef2025-02-03T01:07:59ZengWileyInternational Journal of Microbiology1687-918X1687-91982014-01-01201410.1155/2014/279075279075Effect of Noradrenaline on the Virulence Properties of Campylobacter SpeciesSree V. Aroori0Tristan A. Cogan1Tom J. Humphrey2School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, UKSchool of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, UKNational Centre for Zoonosis Research, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UKCampylobacter species cause a spectrum of illnesses in humans. The type of illness and the outcome is dependent on the virulence of the infecting pathogen strain and host immune status. Acute stress can seriously compromise host immunity and increase susceptibility to infection. Noradrenaline (NA) is a stress hormone. Several studies have shown that it stimulated growth and increased the pathogenicity of organisms including E. coli and Campylobacter jejuni. However, the effect of NA on other Campylobacter species is unknown. We have examined the effect of NA on growth rate, motility, invasion of T84 epithelial cells, and colonisation of chickens by diverse Campylobacter species. Campylobacter cultures grown with NA had reduced lag phases, increased growth rates, and higher final optical densities than controls. The motility of Campylobacter was also significantly increased in the presence of noradrenaline. Some of the Campylobacter strains tested also showed increased invasion of T84 epithelial cells, greater breakdown of tight junctions, and an enhanced potential to colonise chickens. Our results show that noradrenaline-induced enhancement of virulence of Campylobacter can influence the outcome of infection.http://dx.doi.org/10.1155/2014/279075 |
| spellingShingle | Sree V. Aroori Tristan A. Cogan Tom J. Humphrey Effect of Noradrenaline on the Virulence Properties of Campylobacter Species International Journal of Microbiology |
| title | Effect of Noradrenaline on the Virulence Properties of Campylobacter Species |
| title_full | Effect of Noradrenaline on the Virulence Properties of Campylobacter Species |
| title_fullStr | Effect of Noradrenaline on the Virulence Properties of Campylobacter Species |
| title_full_unstemmed | Effect of Noradrenaline on the Virulence Properties of Campylobacter Species |
| title_short | Effect of Noradrenaline on the Virulence Properties of Campylobacter Species |
| title_sort | effect of noradrenaline on the virulence properties of campylobacter species |
| url | http://dx.doi.org/10.1155/2014/279075 |
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