Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid
Objective. Using a novel assay termed prooxidant-antioxidant balance (PAB) assay to determine prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid (MSAF). Passage of meconium in amniotic fluid is associated with increase of neonatal mortality and...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/270545 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548539224293376 |
|---|---|
| author | Mohammad Hassan Arjmand Farhat Ahmad Shah Masoud Saleh Moghadam Fatemeh Tara Amin Jalili Mojtaba Mosavi Bazaz Daryoush Hamidi Alamdari |
| author_facet | Mohammad Hassan Arjmand Farhat Ahmad Shah Masoud Saleh Moghadam Fatemeh Tara Amin Jalili Mojtaba Mosavi Bazaz Daryoush Hamidi Alamdari |
| author_sort | Mohammad Hassan Arjmand |
| collection | DOAJ |
| description | Objective. Using a novel assay termed prooxidant-antioxidant balance (PAB) assay to determine prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid (MSAF). Passage of meconium in amniotic fluid is associated with increase of neonatal mortality and morbidity. This complication occurs in about 15% of infants and is more widespread in postterm neonates. About 1.5 percent of neonates with MSAF develop meconium aspiration syndrome. Method. Sera of 29 umbilical cord blood of infants with MSAF and 32 healthy infants (HI) were collected. Both groups had nonsmoker and non-alcoholic mothers with no diseases. The PAB was measured. Result. There was a significant increase of PAB value (32.8±15.9 HK) in umbilical cord blood of infants with MSAF in comparison to HI (24.5±12.6 HK) (P<0.05). There was no significant correlation between PAB value and age of mothers. Conclusion. The increased PAB value in infants with MSAF showed that these infants are exposed to oxidative stress. Further research with larger population is needed to demonstrate the oxidative stress in infants with MSAF. |
| format | Article |
| id | doaj-art-5a7abef4bd874019bc35224852d0cc60 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-5a7abef4bd874019bc35224852d0cc602025-02-03T06:13:46ZengWileyBiochemistry Research International2090-22472090-22552013-01-01201310.1155/2013/270545270545Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic FluidMohammad Hassan Arjmand0Farhat Ahmad Shah1Masoud Saleh Moghadam2Fatemeh Tara3Amin Jalili4Mojtaba Mosavi Bazaz5Daryoush Hamidi Alamdari6Department of Biology, School of Sciences, Payame Noor University, Mashhad 91735433, IranNeonatal Research Center, Mashhad University of Medical Sciences, Mashhad 9137913316, IranDepartment of Chemistry, School of Science, Payame Noor University, Mashhad 91735433, IranDepartment of Obstetrics and Gynecology, OM-Albanin Hospital, Mashhad University of Medical Sciences, Mashhad 9144663595, IranDepartment of New Science and Technologies, Mashhad University of Medical Sciences, Mashhad 9177948564, IranDepartment of Social Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9138913131, IranStem Cell and Regenerative Medicine Research Group, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, IranObjective. Using a novel assay termed prooxidant-antioxidant balance (PAB) assay to determine prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid (MSAF). Passage of meconium in amniotic fluid is associated with increase of neonatal mortality and morbidity. This complication occurs in about 15% of infants and is more widespread in postterm neonates. About 1.5 percent of neonates with MSAF develop meconium aspiration syndrome. Method. Sera of 29 umbilical cord blood of infants with MSAF and 32 healthy infants (HI) were collected. Both groups had nonsmoker and non-alcoholic mothers with no diseases. The PAB was measured. Result. There was a significant increase of PAB value (32.8±15.9 HK) in umbilical cord blood of infants with MSAF in comparison to HI (24.5±12.6 HK) (P<0.05). There was no significant correlation between PAB value and age of mothers. Conclusion. The increased PAB value in infants with MSAF showed that these infants are exposed to oxidative stress. Further research with larger population is needed to demonstrate the oxidative stress in infants with MSAF.http://dx.doi.org/10.1155/2013/270545 |
| spellingShingle | Mohammad Hassan Arjmand Farhat Ahmad Shah Masoud Saleh Moghadam Fatemeh Tara Amin Jalili Mojtaba Mosavi Bazaz Daryoush Hamidi Alamdari Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid Biochemistry Research International |
| title | Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid |
| title_full | Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid |
| title_fullStr | Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid |
| title_full_unstemmed | Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid |
| title_short | Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid |
| title_sort | prooxidant antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid |
| url | http://dx.doi.org/10.1155/2013/270545 |
| work_keys_str_mv | AT mohammadhassanarjmand prooxidantantioxidantbalanceinumbilicalcordbloodofinfantswithmeconiumstainedofamnioticfluid AT farhatahmadshah prooxidantantioxidantbalanceinumbilicalcordbloodofinfantswithmeconiumstainedofamnioticfluid AT masoudsalehmoghadam prooxidantantioxidantbalanceinumbilicalcordbloodofinfantswithmeconiumstainedofamnioticfluid AT fatemehtara prooxidantantioxidantbalanceinumbilicalcordbloodofinfantswithmeconiumstainedofamnioticfluid AT aminjalili prooxidantantioxidantbalanceinumbilicalcordbloodofinfantswithmeconiumstainedofamnioticfluid AT mojtabamosavibazaz prooxidantantioxidantbalanceinumbilicalcordbloodofinfantswithmeconiumstainedofamnioticfluid AT daryoushhamidialamdari prooxidantantioxidantbalanceinumbilicalcordbloodofinfantswithmeconiumstainedofamnioticfluid |