Pathogenicity and virulence of Francisella tularensis
Tularaemia is a zoonotic disease caused by the Gram-negative bacterium, Francisella tularensis. Depending on its entry route into the organism, F. tularensis causes different diseases, ranging from life-threatening pneumonia to less severe ulceroglandular tularaemia. Various strains with different g...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2023.2274638 |
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| author | Manon Degabriel Stanimira Valeva Sandrine Boisset Thomas Henry |
| author_facet | Manon Degabriel Stanimira Valeva Sandrine Boisset Thomas Henry |
| author_sort | Manon Degabriel |
| collection | DOAJ |
| description | Tularaemia is a zoonotic disease caused by the Gram-negative bacterium, Francisella tularensis. Depending on its entry route into the organism, F. tularensis causes different diseases, ranging from life-threatening pneumonia to less severe ulceroglandular tularaemia. Various strains with different geographical distributions exhibit different levels of virulence. F. tularensis is an intracellular bacterium that replicates primarily in the cytosol of the phagocytes. The main virulence attribute of F. tularensis is the type 6 secretion system (T6SS) and its effectors that promote escape from the phagosome. In addition, F. tularensis has evolved a peculiar envelope that allows it to escape detection by the immune system. In this review, we cover tularaemia, different Francisella strains, and their pathogenicity. We particularly emphasize the intracellular life cycle, associated virulence factors, and metabolic adaptations. Finally, we present how F. tularensis largely escapes immune detection to be one of the most infectious and lethal bacterial pathogens. |
| format | Article |
| id | doaj-art-5a74cf0c192841c5bbad67e4e35468ca |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-5a74cf0c192841c5bbad67e4e35468ca2025-08-20T03:24:55ZengTaylor & Francis GroupVirulence2150-55942150-56082023-12-0114110.1080/21505594.2023.2274638Pathogenicity and virulence of Francisella tularensisManon Degabriel0Stanimira Valeva1Sandrine Boisset2Thomas Henry3CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Univ Lyon, LYON, FranceCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Univ Lyon, LYON, FranceCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Univ Lyon, LYON, FranceCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Univ Lyon, LYON, FranceTularaemia is a zoonotic disease caused by the Gram-negative bacterium, Francisella tularensis. Depending on its entry route into the organism, F. tularensis causes different diseases, ranging from life-threatening pneumonia to less severe ulceroglandular tularaemia. Various strains with different geographical distributions exhibit different levels of virulence. F. tularensis is an intracellular bacterium that replicates primarily in the cytosol of the phagocytes. The main virulence attribute of F. tularensis is the type 6 secretion system (T6SS) and its effectors that promote escape from the phagosome. In addition, F. tularensis has evolved a peculiar envelope that allows it to escape detection by the immune system. In this review, we cover tularaemia, different Francisella strains, and their pathogenicity. We particularly emphasize the intracellular life cycle, associated virulence factors, and metabolic adaptations. Finally, we present how F. tularensis largely escapes immune detection to be one of the most infectious and lethal bacterial pathogens.https://www.tandfonline.com/doi/10.1080/21505594.2023.2274638FrancisellatularaemiaT6SSLPSinnate immunityvirulence |
| spellingShingle | Manon Degabriel Stanimira Valeva Sandrine Boisset Thomas Henry Pathogenicity and virulence of Francisella tularensis Virulence Francisella tularaemia T6SS LPS innate immunity virulence |
| title | Pathogenicity and virulence of Francisella tularensis |
| title_full | Pathogenicity and virulence of Francisella tularensis |
| title_fullStr | Pathogenicity and virulence of Francisella tularensis |
| title_full_unstemmed | Pathogenicity and virulence of Francisella tularensis |
| title_short | Pathogenicity and virulence of Francisella tularensis |
| title_sort | pathogenicity and virulence of francisella tularensis |
| topic | Francisella tularaemia T6SS LPS innate immunity virulence |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2023.2274638 |
| work_keys_str_mv | AT manondegabriel pathogenicityandvirulenceoffrancisellatularensis AT stanimiravaleva pathogenicityandvirulenceoffrancisellatularensis AT sandrineboisset pathogenicityandvirulenceoffrancisellatularensis AT thomashenry pathogenicityandvirulenceoffrancisellatularensis |