Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation

Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation

Abstract Background Cholestatic liver disease, characterized by impaired bile flow, leads to the accumulation of harmful metabolites and toxins, resulting in liver damage. Inflammatory cytokines are crucial for the progression of this condition. Clusterin is a glycoprotein with roles in cell death,...

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Bibliographic Details
Main Authors: Hye-Young Seo, Ji Yeon Park, So-Hee Lee, Hye Won Lee, Eugene Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell & Bioscience
Subjects:
Clusterin
Cholestatic liver
ER stress
NLRP3 inflammasome
Online Access:https://doi.org/10.1186/s13578-025-01376-z
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