Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant Patient
A 47-year-old man with a history of heart transplant was admitted after severe traumatic brain injury and seizures. During mechanical ventilation, the patient developed bronchospasm that severely compromised respiratory function that led to cardiac arrest. After resuscitation, application of isoflur...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/746263 |
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| author | C. Hornuss M. Firsching M. Dolch A. Martignoni A. Peraud J. Briegel |
| author_facet | C. Hornuss M. Firsching M. Dolch A. Martignoni A. Peraud J. Briegel |
| author_sort | C. Hornuss |
| collection | DOAJ |
| description | A 47-year-old man with a history of heart transplant was admitted after severe traumatic brain injury and seizures. During mechanical ventilation, the patient developed bronchospasm that severely compromised respiratory function that led to cardiac arrest. After resuscitation, application of isoflurane through the Anaesthetic Conserving Device (AnaConDa) in the ICU successfully treated bronchospasm, provided adequate sedation, and enabled appropriate ventilation and diagnostic bronchoscopy. A subsequent bronchoalveolar lavage revealed a high amount of Herpes simplex DNA. Herpes simplex pneumonia was diagnosed and treated with acyclovir. Isoflurane treatment was applied for twelve days total without side effects on renal and cerebral function. The patient recovered quickly after the termination of sedation. At discharge, he was fully awake without focal neurological deficiency and his long-term outcome was excellent. This case demonstrates that isoflurane is a treatment option in life-threatening cases of bronchospasm and a safe option for long-term sedation. |
| format | Article |
| id | doaj-art-5a5fad01b5a140aeb50a08fbe6287bf7 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-5a5fad01b5a140aeb50a08fbe6287bf72025-02-03T07:24:26ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/746263746263Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant PatientC. Hornuss0M. Firsching1M. Dolch2A. Martignoni3A. Peraud4J. Briegel5Department of Anaesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of Anaesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of Anaesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of Anaesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of Anaesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyA 47-year-old man with a history of heart transplant was admitted after severe traumatic brain injury and seizures. During mechanical ventilation, the patient developed bronchospasm that severely compromised respiratory function that led to cardiac arrest. After resuscitation, application of isoflurane through the Anaesthetic Conserving Device (AnaConDa) in the ICU successfully treated bronchospasm, provided adequate sedation, and enabled appropriate ventilation and diagnostic bronchoscopy. A subsequent bronchoalveolar lavage revealed a high amount of Herpes simplex DNA. Herpes simplex pneumonia was diagnosed and treated with acyclovir. Isoflurane treatment was applied for twelve days total without side effects on renal and cerebral function. The patient recovered quickly after the termination of sedation. At discharge, he was fully awake without focal neurological deficiency and his long-term outcome was excellent. This case demonstrates that isoflurane is a treatment option in life-threatening cases of bronchospasm and a safe option for long-term sedation.http://dx.doi.org/10.1155/2010/746263 |
| spellingShingle | C. Hornuss M. Firsching M. Dolch A. Martignoni A. Peraud J. Briegel Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant Patient Case Reports in Medicine |
| title | Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant Patient |
| title_full | Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant Patient |
| title_fullStr | Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant Patient |
| title_full_unstemmed | Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant Patient |
| title_short | Long-Term Isoflurane Therapy for Refractory Bronchospasm Associated with Herpes Simplex Pneumonia in a Heart Transplant Patient |
| title_sort | long term isoflurane therapy for refractory bronchospasm associated with herpes simplex pneumonia in a heart transplant patient |
| url | http://dx.doi.org/10.1155/2010/746263 |
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