Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes
Type 1 diabetic (T1D) patients suffer from insulinopenia and hyperglycaemia. Studies have shown that if a patient’s hyperglycaemic environment is not compensated, it leads to complex immune dysfunctions. Similarly, T1D mothers with poor glycaemic control exert a negative impact on the immune respons...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/5463273 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561085691985920 |
|---|---|
| author | Katerina Stechova Jana Sklenarova-Labikova Tereza Kratzerova Pavlina Pithova Dominik Filipp |
| author_facet | Katerina Stechova Jana Sklenarova-Labikova Tereza Kratzerova Pavlina Pithova Dominik Filipp |
| author_sort | Katerina Stechova |
| collection | DOAJ |
| description | Type 1 diabetic (T1D) patients suffer from insulinopenia and hyperglycaemia. Studies have shown that if a patient’s hyperglycaemic environment is not compensated, it leads to complex immune dysfunctions. Similarly, T1D mothers with poor glycaemic control exert a negative impact on the immune responses of their newborns. However, questions concerning the impact of other metabolic disturbances on the immune system of T1D mothers (and their newborns) have been raised. To address these questions, we examined 28 T1D women in reproductive age for the relationship between various metabolic, clinical, and immune parameters. Our study revealed several unexpected correlations which are indicative of a much more complex relationship between glucose and lipid factors (namely, glycosylated haemoglobin Hb1Ac, the presence of one but not multiple chronic diabetic complications, and atherogenic indexes) and proinflammatory cytokines (IL-1alpha and TNF-alpha). Regulatory T cell counts correlated with HbA1c, diabetic neuropathy, lipid spectra parameters, and IL-6 levels. Total T-helper cell count was interconnected with BMI and glycaemia variability correlated with lipid spectra parameters, insulin dose, and vitamin D levels. These and other correlations revealed in this study provide broader insight into the association of various metabolic abnormalities with immune parameters that may impact T1D mothers or their developing child. |
| format | Article |
| id | doaj-art-5a56c9b8f50a40afb292671e017881d8 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5a56c9b8f50a40afb292671e017881d82025-02-03T01:25:57ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/54632735463273Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 DiabetesKaterina Stechova0Jana Sklenarova-Labikova1Tereza Kratzerova2Pavlina Pithova3Dominik Filipp4Department of Internal Medicine, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech RepublicDepartment of Paediatrics, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech RepublicDepartment of Physiology, 2nd Medical Faculty, Charles University, Prague, Czech RepublicDepartment of Internal Medicine, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech RepublicLaboratory of Immunobiology, Institute of Molecular Genetics of the ASCR, Prague, Czech RepublicType 1 diabetic (T1D) patients suffer from insulinopenia and hyperglycaemia. Studies have shown that if a patient’s hyperglycaemic environment is not compensated, it leads to complex immune dysfunctions. Similarly, T1D mothers with poor glycaemic control exert a negative impact on the immune responses of their newborns. However, questions concerning the impact of other metabolic disturbances on the immune system of T1D mothers (and their newborns) have been raised. To address these questions, we examined 28 T1D women in reproductive age for the relationship between various metabolic, clinical, and immune parameters. Our study revealed several unexpected correlations which are indicative of a much more complex relationship between glucose and lipid factors (namely, glycosylated haemoglobin Hb1Ac, the presence of one but not multiple chronic diabetic complications, and atherogenic indexes) and proinflammatory cytokines (IL-1alpha and TNF-alpha). Regulatory T cell counts correlated with HbA1c, diabetic neuropathy, lipid spectra parameters, and IL-6 levels. Total T-helper cell count was interconnected with BMI and glycaemia variability correlated with lipid spectra parameters, insulin dose, and vitamin D levels. These and other correlations revealed in this study provide broader insight into the association of various metabolic abnormalities with immune parameters that may impact T1D mothers or their developing child.http://dx.doi.org/10.1155/2017/5463273 |
| spellingShingle | Katerina Stechova Jana Sklenarova-Labikova Tereza Kratzerova Pavlina Pithova Dominik Filipp Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes Journal of Diabetes Research |
| title | Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes |
| title_full | Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes |
| title_fullStr | Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes |
| title_full_unstemmed | Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes |
| title_short | Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes |
| title_sort | not only glycaemic but also other metabolic factors affect t regulatory cell counts and proinflammatory cytokine levels in women with type 1 diabetes |
| url | http://dx.doi.org/10.1155/2017/5463273 |
| work_keys_str_mv | AT katerinastechova notonlyglycaemicbutalsoothermetabolicfactorsaffecttregulatorycellcountsandproinflammatorycytokinelevelsinwomenwithtype1diabetes AT janasklenarovalabikova notonlyglycaemicbutalsoothermetabolicfactorsaffecttregulatorycellcountsandproinflammatorycytokinelevelsinwomenwithtype1diabetes AT terezakratzerova notonlyglycaemicbutalsoothermetabolicfactorsaffecttregulatorycellcountsandproinflammatorycytokinelevelsinwomenwithtype1diabetes AT pavlinapithova notonlyglycaemicbutalsoothermetabolicfactorsaffecttregulatorycellcountsandproinflammatorycytokinelevelsinwomenwithtype1diabetes AT dominikfilipp notonlyglycaemicbutalsoothermetabolicfactorsaffecttregulatorycellcountsandproinflammatorycytokinelevelsinwomenwithtype1diabetes |