Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery
In this study we have investigated the suitability of a number of different mesoporous silica nanoparticle structures for carrying a drug cargo. We have fully characterized the nanoparticles in terms of their physical parameters; size, surface area, internal pore size and structure. These data are a...
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Wiley
2014-01-01
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| Series: | Nanomaterials and Nanotechnology |
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| Online Access: | http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/characterization-and-comparison-of-mesoporous-silica-particles-for-optimized-drug-delivery |
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| _version_ | 1832558656425558016 |
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| author | Xinyue Huang Neil P Young Helen E Townley |
| author_facet | Xinyue Huang Neil P Young Helen E Townley |
| author_sort | Xinyue Huang |
| collection | DOAJ |
| description | In this study we have investigated the suitability of a number of different mesoporous silica nanoparticle structures for carrying a drug cargo. We have fully characterized the nanoparticles in terms of their physical parameters; size, surface area, internal pore size and structure. These data are all required if we are to make an informed judgement on the suitability of the structure for drug delivery in vivo. With these parameters in mind, we investigated the loading/ unloading profile of a model therapeutic into the pore structure of the nanoparticles. We demonstrate that the release can be controlled by capping the pores on the nanoparticles to achieve temporal control of the unloading. We have also examined the rate and mechanism of the degradation of the nanoparticles over an extended period of time. The eventual dissolution of the nanoparticles after cargo release is a desirable property for a drug delivery system. |
| format | Article |
| id | doaj-art-5a32dc411cee47ac8b1f060d8db9fd09 |
| institution | Kabale University |
| issn | 1847-9804 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Nanomaterials and Nanotechnology |
| spelling | doaj-art-5a32dc411cee47ac8b1f060d8db9fd092025-02-03T01:31:56ZengWileyNanomaterials and Nanotechnology1847-98042014-01-0142http://dx.doi.org/10.5772/5829046137Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug DeliveryXinyue HuangNeil P YoungHelen E TownleyIn this study we have investigated the suitability of a number of different mesoporous silica nanoparticle structures for carrying a drug cargo. We have fully characterized the nanoparticles in terms of their physical parameters; size, surface area, internal pore size and structure. These data are all required if we are to make an informed judgement on the suitability of the structure for drug delivery in vivo. With these parameters in mind, we investigated the loading/ unloading profile of a model therapeutic into the pore structure of the nanoparticles. We demonstrate that the release can be controlled by capping the pores on the nanoparticles to achieve temporal control of the unloading. We have also examined the rate and mechanism of the degradation of the nanoparticles over an extended period of time. The eventual dissolution of the nanoparticles after cargo release is a desirable property for a drug delivery system.http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/characterization-and-comparison-of-mesoporous-silica-particles-for-optimized-drug-deliveryNanoparticleSilicaMesoporousMorphologyCargoDegradation |
| spellingShingle | Xinyue Huang Neil P Young Helen E Townley Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery Nanomaterials and Nanotechnology Nanoparticle Silica Mesoporous Morphology Cargo Degradation |
| title | Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery |
| title_full | Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery |
| title_fullStr | Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery |
| title_full_unstemmed | Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery |
| title_short | Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery |
| title_sort | characterization and comparison of mesoporous silica particles for optimized drug delivery |
| topic | Nanoparticle Silica Mesoporous Morphology Cargo Degradation |
| url | http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/characterization-and-comparison-of-mesoporous-silica-particles-for-optimized-drug-delivery |
| work_keys_str_mv | AT xinyuehuang characterizationandcomparisonofmesoporoussilicaparticlesforoptimizeddrugdelivery AT neilpyoung characterizationandcomparisonofmesoporoussilicaparticlesforoptimizeddrugdelivery AT helenetownley characterizationandcomparisonofmesoporoussilicaparticlesforoptimizeddrugdelivery |