Immunomodulatory Effects of Tigecycline in Balb/C Mice
Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for this side effect. Previous reports found a po...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0040 |
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| author | Elhayek Shada Y. Fararjeh Mohammad A. Assaf Areej M. Abu-Rish Eman Y. Bustanji Yasser |
| author_facet | Elhayek Shada Y. Fararjeh Mohammad A. Assaf Areej M. Abu-Rish Eman Y. Bustanji Yasser |
| author_sort | Elhayek Shada Y. |
| collection | DOAJ |
| description | Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for this side effect. Previous reports found a possible effect of tigecycline on leukocyte proliferation and proinflammatory cytokine release. We t herefore i nvestigated the effect of tigecycline on the immune components and response in Balb/c mice in vivo and in vitro. It was found that tigecycline enhanced lymphocyte proliferation and significantly increased cellular infiltration within the footpad, as based on DTH testing, but reduced the hemagglutination titer. In splenocyte cultures, tigecycline suppressed splenocyte proliferation with IC50 3-5 mmol L-1, significantly increased IL-2 secretion and reduced IL-17 secretion in a dose dependent mode. In conclusion, tigecycline is safe at therapeutic and sub-therapeutic doses, but it could still have an immunomodulatory effect at higher doses. Use of higher doses of tigecycline requires further investigation. |
| format | Article |
| id | doaj-art-5a2de0eac14247c6b16e44c83b398e2b |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-5a2de0eac14247c6b16e44c83b398e2b2025-02-02T17:46:44ZengSciendoActa Pharmaceutica1846-95582018-12-0168445746910.2478/acph-2018-0040acph-2018-0040Immunomodulatory Effects of Tigecycline in Balb/C MiceElhayek Shada Y.0Fararjeh Mohammad A.1Assaf Areej M.2Abu-Rish Eman Y.3Bustanji Yasser4Department of Biopharmaceutics and Clinical Pharmacy School of Pharmacy, University of Jordan,Amman, JordanAl-Quds Medical Labs, AL-Zarqa, JordanDepartment of Biopharmaceutics and Clinical Pharmacy School of Pharmacy, University of Jordan,Amman, JordanDepartment of Biopharmaceutics and Clinical Pharmacy School of Pharmacy, University of Jordan,Amman, JordanDepartment of Biopharmaceutics and Clinical Pharmacy School of Pharmacy, University of Jordan,Amman, JordanTigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for this side effect. Previous reports found a possible effect of tigecycline on leukocyte proliferation and proinflammatory cytokine release. We t herefore i nvestigated the effect of tigecycline on the immune components and response in Balb/c mice in vivo and in vitro. It was found that tigecycline enhanced lymphocyte proliferation and significantly increased cellular infiltration within the footpad, as based on DTH testing, but reduced the hemagglutination titer. In splenocyte cultures, tigecycline suppressed splenocyte proliferation with IC50 3-5 mmol L-1, significantly increased IL-2 secretion and reduced IL-17 secretion in a dose dependent mode. In conclusion, tigecycline is safe at therapeutic and sub-therapeutic doses, but it could still have an immunomodulatory effect at higher doses. Use of higher doses of tigecycline requires further investigation.https://doi.org/10.2478/acph-2018-0040tigecyclineimmunomodulationbalb/c micebiochemical effect |
| spellingShingle | Elhayek Shada Y. Fararjeh Mohammad A. Assaf Areej M. Abu-Rish Eman Y. Bustanji Yasser Immunomodulatory Effects of Tigecycline in Balb/C Mice Acta Pharmaceutica tigecycline immunomodulation balb/c mice biochemical effect |
| title | Immunomodulatory Effects of Tigecycline in Balb/C Mice |
| title_full | Immunomodulatory Effects of Tigecycline in Balb/C Mice |
| title_fullStr | Immunomodulatory Effects of Tigecycline in Balb/C Mice |
| title_full_unstemmed | Immunomodulatory Effects of Tigecycline in Balb/C Mice |
| title_short | Immunomodulatory Effects of Tigecycline in Balb/C Mice |
| title_sort | immunomodulatory effects of tigecycline in balb c mice |
| topic | tigecycline immunomodulation balb/c mice biochemical effect |
| url | https://doi.org/10.2478/acph-2018-0040 |
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