Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid
Coronavirus disease (COVID-19) causes damage through mechanisms: cytotoxic to the bile duct, liver and renal tubular epithelial cells; severe inflammatory response due to excessive pro-inflammatory cytokines (cytokine storm); tissue anoxia; and drug-induced liver and kidney damage. AST and ALT enzym...
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Faculty of Medicine at Universitas Andalas
2021-09-01
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| Series: | Jurnal Kesehatan Andalas |
| Online Access: | http://jurnal.fk.unand.ac.id/index.php/jka/article/view/1722 |
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| author | Rachmi Fadillah Ellyza Nasrul Tuty Prihandani |
| author_facet | Rachmi Fadillah Ellyza Nasrul Tuty Prihandani |
| author_sort | Rachmi Fadillah |
| collection | DOAJ |
| description | Coronavirus disease (COVID-19) causes damage through mechanisms: cytotoxic to the bile duct, liver and renal tubular epithelial cells; severe inflammatory response due to excessive pro-inflammatory cytokines (cytokine storm); tissue anoxia; and drug-induced liver and kidney damage. AST and ALT enzymes are used to determine liver damage, while kidney damage is examined from increased urea and creatinine levels. Objectives: To know AST, ALT, urea and creatinine levels in COVID-19 patients with and without comorbidity in RSUP Dr. M. Djamil Padang. Methods: A retrospective descriptive study was conducted by taking chemical data for COVID-19 patients with and without comorbidity for March-August 2020. AST and ALT levels were examined by using an automatic chemistry analyzer with NADH method (without P-5'-P), urea with enzymatic colorimetry, and creatinine with Jaffe's modification. The data was presented in table and average (standard deviation). Results: A study of 76 patients found 28 with comorbidity and 48 without comorbidity. Patients with comorbidity AST in average was 33.0 (20.3) U/l; SGPT 29.0 (23.4) U/l; urea 58.3 (66.9) mg/dl; and creatinine 3.0 (5.1) mg/dl. Patients without comorbidity AST in average 31.9 (28.7) mg/dl; SGPT 28.8 (21.4) mg/dl; urea 24.6 (20.1) mg/dl; creatinine 0.9 (0.4) mg/dl. In average, AST and ALT in patients with and without comorbidity were in the normal range. Urea and creatinine in patients with comorbidity were higher than normal. Conclusion: Covid-19 patients with comorbidity at admission had urea and creatinine levels in average higher than normal values.
Keywords: aminotransaminase, COVID-19, creatinine |
| format | Article |
| id | doaj-art-5a2d8ac5a8be4ac4a85aa4c1685588ca |
| institution | Kabale University |
| issn | 2301-7406 2615-1138 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Faculty of Medicine at Universitas Andalas |
| record_format | Article |
| series | Jurnal Kesehatan Andalas |
| spelling | doaj-art-5a2d8ac5a8be4ac4a85aa4c1685588ca2025-02-03T11:08:42ZengFaculty of Medicine at Universitas AndalasJurnal Kesehatan Andalas2301-74062615-11382021-09-0110210711310.25077/jka.v10i2.17221188Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa KomorbidRachmi Fadillah0Ellyza Nasrul1Tuty Prihandani2RSUP Dr. M.Djamil, Padang.Bagian Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang.Bagian Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang.Coronavirus disease (COVID-19) causes damage through mechanisms: cytotoxic to the bile duct, liver and renal tubular epithelial cells; severe inflammatory response due to excessive pro-inflammatory cytokines (cytokine storm); tissue anoxia; and drug-induced liver and kidney damage. AST and ALT enzymes are used to determine liver damage, while kidney damage is examined from increased urea and creatinine levels. Objectives: To know AST, ALT, urea and creatinine levels in COVID-19 patients with and without comorbidity in RSUP Dr. M. Djamil Padang. Methods: A retrospective descriptive study was conducted by taking chemical data for COVID-19 patients with and without comorbidity for March-August 2020. AST and ALT levels were examined by using an automatic chemistry analyzer with NADH method (without P-5'-P), urea with enzymatic colorimetry, and creatinine with Jaffe's modification. The data was presented in table and average (standard deviation). Results: A study of 76 patients found 28 with comorbidity and 48 without comorbidity. Patients with comorbidity AST in average was 33.0 (20.3) U/l; SGPT 29.0 (23.4) U/l; urea 58.3 (66.9) mg/dl; and creatinine 3.0 (5.1) mg/dl. Patients without comorbidity AST in average 31.9 (28.7) mg/dl; SGPT 28.8 (21.4) mg/dl; urea 24.6 (20.1) mg/dl; creatinine 0.9 (0.4) mg/dl. In average, AST and ALT in patients with and without comorbidity were in the normal range. Urea and creatinine in patients with comorbidity were higher than normal. Conclusion: Covid-19 patients with comorbidity at admission had urea and creatinine levels in average higher than normal values. Keywords: aminotransaminase, COVID-19, creatininehttp://jurnal.fk.unand.ac.id/index.php/jka/article/view/1722 |
| spellingShingle | Rachmi Fadillah Ellyza Nasrul Tuty Prihandani Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid Jurnal Kesehatan Andalas |
| title | Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid |
| title_full | Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid |
| title_fullStr | Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid |
| title_full_unstemmed | Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid |
| title_short | Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid |
| title_sort | gambaran pemeriksaan kadar sgot sgpt ureum dan kreatinin pasien covid 19 dengan dan tanpa komorbid |
| url | http://jurnal.fk.unand.ac.id/index.php/jka/article/view/1722 |
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