Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents

Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents

Several Schiff bases 2 have been prepared by the condensation of various methyl ketones 1 with 1,2-ethylenediamine. Subsequent acylation of these Schiff bases with trifluoroacetic anhydride in THF yields the corresponding trifluoroacetyl derivatives 3. However, o-hydroxy- and o-methoxy-substituted d...

Full description

Saved in:

Bibliographic Details
Main Authors:	Khalid A. Khan, Hassan M. Faidallah, Abdullah M. Asiri
Format:	Article
Language:	English
Published:	Wiley 2013-01-01
Series:	Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2013/478635
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis and X-Ray Structure of (1Z,2Z)-1,2-Bis(2-(phenylsulfonyl)-1-(4-tolyl)ethylidene)hydrazine
by: Hatem A. Abdel-Aziz, et al.
Published: (2014-01-01)

The crystal structure of 1,2-bis(4-pyridyl)ethane - 4,4-dihydroxydiphenylmethane (1/1), C25H21N2O2
by: Cheng Jie, et al.
Published: (2021-09-01)

Crystal structure of 1,2-bis(4,5-dinitro-1H-imidazol-1-yl)ethane, C8H6N8O8
by: Yong Wang, et al.
Published: (2022-08-01)

Spectral Characterization and Crystal Structure of 1,2-Bis-(1H-benzimidazol-2-yl)-ethane Dihydrochloride
by: Aydin Tavman, et al.
Published: (2013-01-01)

Crystal structure of 1,2-bis(2,4-dinitro-1H-imidazol-1-yl)ethane – dimethylformamide (1/1), C11H13N9O9
by: Jun Yuan, et al.
Published: (2022-08-01)

The crystal structure of 1,2-bis(pyridinium-4-yl)ethane diperchlorate, C12H14N2·2ClO4 – a second polymorph
by: Qiu Qi-Ming, et al.
Published: (2022-08-01)

The crystal structure of (Z)-4-amino-N′-(1-(o-tolyl)ethylidene)benzohydrazide, C16H17N3O
by: Qiao Ai-Li, et al.
Published: (2023-08-01)

The crystal structure of (4-hydroxybenzenesulfonate)-k1O-6,6′-((1E,1′E)- (ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene)) bis(2-methoxyphenol)-κ2N,N,μ2O,O,κ2O, O)-(methanol)-cobalt(II) sodium(I), C25H27CoN2NaO9S
by: Zhang Shaoliang, et al.
Published: (2023-10-01)

Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives
by: Elaine S. Coimbra, et al.
Published: (2008-01-01)

Crystal structure of trans-N 1,N 8-bis(2-cyanoethyl)-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, C22H42N6
by: Rabi Saswata, et al.
Published: (2023-08-01)

Crystal structure of [N(E),N′(E)]-N,N′-(1,4-phenylenedimethylidyne)bis-3,5-bis(propan-2-yl)-1H-pyrazol-4-amine, C26H36N6
by: Fujisawa Kiyoshi, et al.
Published: (2023-10-01)

The crystal structure of N,N′-(1,2-phenylene)bis (2-((2-oxopropyl)selanyl)benzamide), C26H24N2O4Se2
by: Feng Shuxiao, et al.
Published: (2023-08-01)

The crystal structure of N,N′-((nitroazanediyl)bis(methylene))diacetamide, C6H12O4N4
by: Cong Chen, et al.
Published: (2023-10-01)

Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes
by: Muhammad Jamil, et al.
Published: (2013-01-01)

Crystal structure of poly[diaqua-(bis(μ2-1,4-bis(imidazol-1-ylmethyl)benzene)-κ2N,N′] cobalt(II)-tetraqua-bis(1,4-bis(imidazol-1-ylmethyl)benzene)-κ1N)-cobalt(II) di(2,5-thiophenedicarboxylate) dihydrate, C68H76Co2N16O16S2
by: Chen Jie, et al.
Published: (2023-10-01)

Crystal structure of poly[bis[μ3-1,3,5-tris[(1H-imidazol-1-yl)methyl]benzene-κ3N:N′:N″]nickel(II)] hexafluorosilicate, C36H36N12NiSiF6
by: Xu Xi‐Ting, et al.
Published: (2021-09-01)

The crystal structure of (1E,2E)-1,2-bis(quinolin-2-ylmethylene)hydrazine, C20H14N4
by: Liao Fuguang, et al.
Published: (2023-08-01)

The crystal structure of diaqua-bis(2-(3-(1H-pyrazol-4-yl)-1H-1,2,4-triazol-5-yl)pyridine-κ2 N:N′)-bis(3,5-dicarboxybenzoato-κ1 O)cobalt(II), C38H30CoN12O14
by: Yong-Hua Zhang, et al.
Published: (2021-09-01)

Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
by: Jun-Rong Jiang, et al.
Published: (2016-01-01)

Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats
by: Tahia H. Saleem, et al.
Published: (2018-01-01)

Crystal structure of catena-poly[bis(μ2-azido-k2N:N′)-(nitrato-K2N:N′)-bis(1,10-phenanthroline-K2N:N′)samarium(III)], C24H16N11O3Sm
by: Feng Yu-Quan
Published: (2023-10-01)

Construction of Eu3+ Ion-Selective Electrode Based on 1,2-Diaminopropane-N,N,N',N'-tetraacetic acid
by: Mohammad Reza Abedi, et al.
Published: (2011-01-01)

Synthesis, Thermal Properties and Nucleating Effect of N, N, N, N'-Tetra(benzoyl) Ethylene Diamine Tetraacetic Acid Dihydrazide as Nucleating Agent of Poly(L-lactic acid)
by: Yan-Hua Cai
Published: (2012-01-01)

Generation of Mature Nα-Terminal Acetylated Thymosin α1 by Cleavage of Recombinant Prothymosin α
by: Bo Liu, et al.
Published: (2013-01-01)

The crystal structure of bis(μ2-5-chloro-2-oxido-N-(1-oxidopropylidene)benzohydrazonato-κ5 N,O,O′:N′,O′′)-octakis(pyridine-κ1 N)trinickel(II) C60H56Cl2N12Ni3O6
by: Xin Wang, et al.
Published: (2022-08-01)

Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats
by: Salma Tabassum, et al.
Published: (2014-01-01)

The crystal structure of 1,1′-(((2 (dimethylamino)ethyl)azanediyl)bis(methylene)) bis(naphthalen-2-olato-κ4 N,N′,O,O′)-(pyridine-2,6-dicarboxylato-N,O,O′)- titanium(IV) ─ dichloromethane (2/1), C33H29N3O6Ti
by: Zhao Tiankun, et al.
Published: (2021-09-01)

X(n+1)=max{1/x(n-1),y(n)/x(n)};y(n+1)=max{1/y(n-1),x(n)/y(n)} Maksimumlu Fark Denklem Sisteminin Çözümleri
by: D. Şimşek, et al.
Published: (2016-05-01)

Crystal structure of bis(μ2-azido-κ2N:N)-tetrakis(azido-κ1N)-tetrakis(1,10-phenanthroline-κ2N,N′)dibismuth(III), C48H32N26Bi2
by: Zhong Zhi-Guo, et al.
Published: (2023-10-01)

Kinetics of Mushroom Tyrosinase and Melanogenesis Inhibition by N-Acetyl-pentapeptides
by: Ching-Yi Lien, et al.
Published: (2014-01-01)

Illuminating the impact of N-terminal acetylation: from protein to physiology
by: Nina McTiernan, et al.
Published: (2025-01-01)

The crystal structure of (N-([1,1′:4′,1″-terphenyl]-4,4′-diethyl)-2-(bis(pyridin-2-ylmethyl)amino)acetamide-κ4N,N,N″, O)tri(nitrato-kO, O′) samarium(III) - methanol - acetonitrile (1/1/1), C40H39SmN8O14
by: Wang Hai-Ping, et al.
Published: (2023-10-01)

Application of N-Acetyl-Glucosaminil-N-Acetyl-Muramyl Dipeptide during Triple Component Anti-Helicobacter Pylori Therapy in the Period of Coronavirus Infection COVID-19
by: M. R. Konorev, et al.
Published: (2023-08-01)

The crystal structure of diaqua-bis(pyrazolo[1,5-a]pyrimidine-3-carboxylato-κ2N,O)manganese(II), C14H12N6O6Mn
by: Hong Dong-Feng, et al.
Published: (2022-08-01)

Crystal structure of rac-1,8-bis(2-carbamoylethyl)-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, C22H46N6O2
by: Paul Pradip, et al.
Published: (2023-08-01)

Crystal structure of [N(E),N′(E)]-N,N′-(1,4-phenylenedimethylidyne)bis-3,5-dimethyl-1H-pyrazol-4-amine di-methanol solvate, C18H20N6·2(CH3OH)
by: Fujisawa Kiyoshi, et al.
Published: (2023-10-01)

Synthesis, Characterization and Antitumor Activity of cis-bis(acylthioureato) platinum(II) Complexes, cis-[PtL2] [HL1=N,N-Diphenyl-N'-Benzoylthiourea or HL2=N,N-diphenyl-N'-(p-nitrobenzoyl)thiourea]
by: Wilfredo Hernández, et al.
Published: (2003-01-01)

Crystal structure of 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene-N,N′-bis(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-1,3,2-diazaborol-2-yl)-l2-germenediamine, C63H94B2GeN8
by: Wang Bing, et al.
Published: (2023-10-01)

The crystal structure of N′1,N′3-bis((E)-thiophen-2-ylmethylene)isophthalohydrazide monohydrate, C18H16N4O3S2
by: Yin Zi-Yi, et al.
Published: (2023-08-01)

Crystal structure of 2-bromo-1,3,6,8-tetramethylBOPHY (BOPHY = bis(difluoroboron)-1,2-bis((1H-pyrrol-2-yl)methylene)hydrazine), C14H15B2BrF4N4
by: He Weifeng, et al.
Published: (2021-09-01)