Clinical profile, response and outcome of various immunosuppressive regimens used for treatment of idiopathic membranous nephropathy—a retrospective cohort study
Background: Membranous nephropathy (MN) is a glomerular disease commonly presenting as a nephrotic syndrome in adults. Various immunosuppressive medications have been used in the treatment of the same with different levels of success. Hence we have undertaken a retrospective analysis of “Clinical...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Troika Publisher
2024-12-01
|
| Series: | Journal of Renal and Hepatic Disorders |
| Subjects: | |
| Online Access: | https://www.jrenhep.com/index.php/jrenhep/article/view/200/349 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: Membranous nephropathy (MN) is a glomerular disease
commonly presenting as a nephrotic syndrome in adults. Various immunosuppressive
medications have been used in the treatment of the same with different levels of
success. Hence we have undertaken a retrospective analysis of “Clinical profile,
response and outcome of various immunosuppressive regimens used for treatment of
membranous nephropathy” to determine the efficacy of each treatment
regimen. Methods: A retrospective observational cohort study was
conducted in a single tertiary care centre in southern India. Patients with
proven primary membranous nephropathy from 2010 to June 2020 with a minimum
duration of follow-up of one year and treated with different immunosuppressive
regimens were included in the study. Results: The total number of
patients in the study was 129. Mean age of onset was 39 years with a follow-up of
a minimum of 1 year and a maximum of 10 years, the mean follow-up being 3 years.
46.5% achieved complete remission, 23.3% had partial remission and 10.9% had
relapse, doubling of serum creatinine was seen in 5 (3.9%) and chronic kidney
failure requiring kidney replacement therapy in 3 (2.3%) respectively. Presence
of interstitial fibrosis and tubular atrophy (IFTA) had a significant correlation
p-value 0.02, patients with IFTA less than 30% performed the best with
54/71 patients (60%) achieving remission. Conclusions: Hypertension and
IFTA at presentation were predictors for worse outcomes. modified Ponticelli,
followed by rituximab, were the most effective in inducing and maintaining
remission. |
|---|---|
| ISSN: | 2207-3744 |