Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology
Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review present...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2021/9954443 |
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| author | Chukwuebuka Egbuna Vijaykumar K. Parmar Jaison Jeevanandam Shahira M. Ezzat Kingsley C. Patrick-Iwuanyanwu Charles Oluwaseun Adetunji Johra Khan Eugene N. Onyeike Chukwuemelie Zedech Uche Muhammad Akram Mervat S. Ibrahim Nihal M. El Mahdy Chinaza Godswill Awuchi Kaliyaperumal Saravanan Habibu Tijjani Uchenna Estella Odoh Mohammed Messaoudi Jonathan C. Ifemeje Michael C. Olisah Nebechi Jane Ezeofor Chukwudi Jude Chikwendu Chinwe Gloria Ibeabuchi |
| author_facet | Chukwuebuka Egbuna Vijaykumar K. Parmar Jaison Jeevanandam Shahira M. Ezzat Kingsley C. Patrick-Iwuanyanwu Charles Oluwaseun Adetunji Johra Khan Eugene N. Onyeike Chukwuemelie Zedech Uche Muhammad Akram Mervat S. Ibrahim Nihal M. El Mahdy Chinaza Godswill Awuchi Kaliyaperumal Saravanan Habibu Tijjani Uchenna Estella Odoh Mohammed Messaoudi Jonathan C. Ifemeje Michael C. Olisah Nebechi Jane Ezeofor Chukwudi Jude Chikwendu Chinwe Gloria Ibeabuchi |
| author_sort | Chukwuebuka Egbuna |
| collection | DOAJ |
| description | Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. The extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others. |
| format | Article |
| id | doaj-art-5a22642f03d84905a4a4b3c4c75ba9ec |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-5a22642f03d84905a4a4b3c4c75ba9ec2025-02-03T07:23:29ZengWileyJournal of Toxicology1687-81911687-82052021-01-01202110.1155/2021/99544439954443Toxicity of Nanoparticles in Biomedical Application: NanotoxicologyChukwuebuka Egbuna0Vijaykumar K. Parmar1Jaison Jeevanandam2Shahira M. Ezzat3Kingsley C. Patrick-Iwuanyanwu4Charles Oluwaseun Adetunji5Johra Khan6Eugene N. Onyeike7Chukwuemelie Zedech Uche8Muhammad Akram9Mervat S. Ibrahim10Nihal M. El Mahdy11Chinaza Godswill Awuchi12Kaliyaperumal Saravanan13Habibu Tijjani14Uchenna Estella Odoh15Mohammed Messaoudi16Jonathan C. Ifemeje17Michael C. Olisah18Nebechi Jane Ezeofor19Chukwudi Jude Chikwendu20Chinwe Gloria Ibeabuchi21Africa Centre of Excellence in Public Health and Toxicological Research (ACE-PUTOR), Nutritional Biochemistry and Toxicology Unit, University of Port-Harcourt, Port Harcourt, Rivers State, NigeriaDepartment of Pharmaceutical Sciences, Sardar Patel University, Vallabh Vidyanagar - 388 120, Gujarat, IndiaCQM–Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, PortugalDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El Ainy Street, 11562 Cairo, EgyptAfrica Centre of Excellence in Public Health and Toxicological Research (ACE-PUTOR), Nutritional Biochemistry and Toxicology Unit, University of Port-Harcourt, Port Harcourt, Rivers State, NigeriaApplied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo University Iyamho, PMB 04 Auchi, Edo State, NigeriaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi ArabiaAfrica Centre of Excellence in Public Health and Toxicological Research (ACE-PUTOR), Nutritional Biochemistry and Toxicology Unit, University of Port-Harcourt, Port Harcourt, Rivers State, NigeriaDepartment of Medical Biochemistry and Molecular Biology, Faculty of Basic Medical Sciences, University of Nigeria, Enugu Campus, Nsukka, NigeriaDepartment of Eastern Medicines, Government College University, Faisalabad, PakistanDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October 12566, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October 12566, EgyptSchool of Natural and Applied Sciences, Kampala International University, Kampala, UgandaPG and Research Department of Zoology, Nehru Memorial College (Autonomous), Puthanampatti–621 007, Bharathidasan University, Tiruchirappalli, Tamil Nadu, IndiaDepartment of Biochemistry, Natural Product Research Laboratory, Bauchi State University, Gadau, NigeriaDepartment of Pharmacognosy and Environmental Medicines, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, NigeriaNuclear Research Centre of Birine, Ain Oussera, P.O. Box 180, Djelfa 17200, AlgeriaDepartment of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 431124, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 431124, NigeriaDepartment of Food Technology, School of Applied Science and Technology, Federal Polytechnic, Oko, Anambra State, NigeriaDepartment of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 431124, NigeriaAfrica Centre of Excellence in Public Health and Toxicological Research (ACE-PUTOR), Nutritional Biochemistry and Toxicology Unit, University of Port-Harcourt, Port Harcourt, Rivers State, NigeriaNanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. The extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.http://dx.doi.org/10.1155/2021/9954443 |
| spellingShingle | Chukwuebuka Egbuna Vijaykumar K. Parmar Jaison Jeevanandam Shahira M. Ezzat Kingsley C. Patrick-Iwuanyanwu Charles Oluwaseun Adetunji Johra Khan Eugene N. Onyeike Chukwuemelie Zedech Uche Muhammad Akram Mervat S. Ibrahim Nihal M. El Mahdy Chinaza Godswill Awuchi Kaliyaperumal Saravanan Habibu Tijjani Uchenna Estella Odoh Mohammed Messaoudi Jonathan C. Ifemeje Michael C. Olisah Nebechi Jane Ezeofor Chukwudi Jude Chikwendu Chinwe Gloria Ibeabuchi Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology Journal of Toxicology |
| title | Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology |
| title_full | Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology |
| title_fullStr | Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology |
| title_full_unstemmed | Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology |
| title_short | Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology |
| title_sort | toxicity of nanoparticles in biomedical application nanotoxicology |
| url | http://dx.doi.org/10.1155/2021/9954443 |
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